PDB: 237 件ウェブページステータス検索Chemie searchBIRD

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1NHX	PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR 分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ... 著者 Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J. 登録日 2002-12-19 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
4GMZ	Structure of rat cytosolic PEPCK Ld_2g in complex with Beta-Sulfopyruvate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-16 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNP	Structure of rat cytosolic PEPCK Ld_3g in complex with PEP and GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-17 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.744 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNO	Structure of rat cytosolic PEPCK Ld_3g in complex with Beta-Sulfopyruvate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-17 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNL	Structure of rat cytosolic PEPCK Ld_2g in complex with PEP and GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-17 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMM	Structure of rat cytosolic PEPCK Ld_1g in complex with Beta-Sulfopyruvate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-16 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.736 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMW	Structure of rat cytosolic PEPCK Ld_1g in complex with PEP and GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-16 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMU	Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-16 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNQ	Structure of rat cytosolic PEPCK Ld_3g in complex with oxalate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-17 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNM	Structure of rat cytosolic PEPCK Ld_2g in complex with oxalate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2012-08-17 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
2QF2	Rat cytosolic PEPCK in complex with oxaloacetic acid and GDP. 分子名称: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, OXALOACETATE ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2007-06-26 公開日 2007-08-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
2QF1	Rat cytosolic PEPCK in complex with oxaloacetic acid. 分子名称: MANGANESE (II) ION, OXALOACETATE ION, Phosphoenolpyruvate carboxykinase, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2007-06-26 公開日 2007-08-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
2QEY	Rat cytosolic PEPCK in complex with GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2007-06-26 公開日 2007-08-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
2QEW	Rat cytosolic PEPCK, in complex with manganese ion. 分子名称: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2007-06-26 公開日 2007-08-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry, 46, 2007
2RKD	The Structure of rat cytosolic PEPCK in complex with 3-phosphonopropionate 分子名称: 3-PHOSPHONOPROPANOIC ACID, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T. 登録日 2007-10-16 公開日 2008-01-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition. Biochemistry, 47, 2008
2RK8	The Structure of rat cytosolic PEPCK in complex with phosphonoformate 分子名称: DI(HYDROXYETHYL)ETHER, FORMIC ACID, MANGANESE (II) ION, ... 著者 Sullivan, S.M, Stiffin, R.M, Carlson, G.M, Holyoak, T. 登録日 2007-10-16 公開日 2008-01-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition. Biochemistry, 47, 2008
7NWK	Crystal structure of CDK9-Cyclin T1 bound by compound 6 分子名称: Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide 著者 Collie, G.W, Ferguson, A.D. 登録日 2021-03-16 公開日 2021-10-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64, 2021
6Z45	CDK9-Cyclin-T1 complex bound by compound 24 分子名称: (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... 著者 Ferguson, A, Collie, G.W. 登録日 2020-05-22 公開日 2020-12-23 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
7QGS	Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) 分子名称: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION 著者 Hegedus, Z, Wilson, A.J, Edwards, T.A. 登録日 2021-12-10 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Understanding p300-transcription factor interactions using sequence variation and hybridization. Rsc Chem Biol, 3, 2022
1YNW	Crystal Structure of Vitamin D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element 分子名称: 5'-d(*TP*TP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*AP*A)-3', 5'-d(*TP*TP*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*A)-3', Retinoic acid receptor RXR-alpha, ... 著者 Shaffer, P.L, Gewirth, D.T. 登録日 2005-01-25 公開日 2005-02-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural analysis of RXR-VDR interactions on DR3 DNA J.Steroid Biochem.Mol.Biol., 89-90, 2004
7CD5	mAPE1-blunt-ended dsDNA product complex 分子名称: DNA(5'-D(*CP*GP*TP*AP*AP*TP*AP*CP*G)-3'), DNA-(apurinic or apyrimidinic site) endonuclease 著者 Liu, T.C, Hsiao, Y.Y. 登録日 2020-06-18 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling. Nat Commun, 12, 2021
1DSZ	STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 分子名称: DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*G)-3'), RETINOIC ACID RECEPTOR ALPHA, ... 著者 Rastinejad, F, Wagner, T, Zhao, Q, Khorasanizadeh, S. 登録日 2000-01-10 公開日 2000-07-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. EMBO J., 19, 2000
8CDK	CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2023-01-31 公開日 2023-04-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
6W9E	Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295 分子名称: (4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone, Cyclin-T1, ... 著者 Zhang, P, Wu, J. 登録日 2020-03-22 公開日 2021-09-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships To Be Published
2WP2	Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide. 分子名称: BROMODOMAIN TESTIS-SPECIFIC PROTEIN, HISTONE H4 著者 Moriniere, J, Rousseaux, S, Steuerwald, U, Soler-Lopez, M, Curtet, S, Vitte, A.-L, Govin, J, Gaucher, J, Sadoul, K, Hart, D.J, Krijgsveld, J, Khochbin, S, Mueller, C.W, Petosa, C. 登録日 2009-08-02 公開日 2009-09-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Cooperative Binding of Two Acetylation Marks on a Histone Tail by a Single Bromodomain. Nature, 461, 2009

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