1JXE
 
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7C7E
 | | Crystal structure of C terminal domain of Escherichia coli DgoR | | 分子名称: | Putative DNA-binding transcriptional regulator, SULFATE ION, TRIETHYLENE GLYCOL, ... | | 著者 | Lin, W. | | 登録日 | 2020-05-25 | | 公開日 | 2021-01-20 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket.
Front Microbiol, 11, 2020
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2PYO
 | | Drosophila nucleosome core | | 分子名称: | CHLORIDE ION, DNA (147-MER), Histone H2A, ... | | 著者 | Clapier, C.R, Petosa, C, Mueller, C.W. | | 登録日 | 2007-05-16 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer.
Proteins, 71, 2007
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8J90
 | | Cryo-EM structure of DDM1-nucleosome complex | | 分子名称: | ATP-dependent DNA helicase DDM1, DNA (169-MER), HTA6, ... | | 著者 | Osakabe, A, Takizawa, Y, Horikoshi, N, Hatazawa, S, Berger, F, Kurumizaka, H, Kakutani, T. | | 登録日 | 2023-05-02 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (4.71 Å) | | 主引用文献 | Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1.
Nat Commun, 15, 2024
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6S9R
 | | Crystal structure of SSDP from D. melanogaster | | 分子名称: | Sequence-specific single-stranded DNA-binding protein, isoform A | | 著者 | Renko, M, Bienz, M. | | 登録日 | 2019-07-15 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7AW2
 | | MerTK kinase domain with type 1.5 inhibitor from a DNA-encoded library | | 分子名称: | 5-(2'-chloro-[1,1'-biphenyl]-4-yl)-N-(imidazo[1,2-a]pyridin-6-ylmethyl)-N-methyl-1,3,4-oxadiazol-2-amine, Tyrosine-protein kinase Mer | | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | | 登録日 | 2020-11-06 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64, 2021
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8KCB
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8KCC
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1ID3
 | | CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS | | 分子名称: | HISTONE H2A.1, HISTONE H2B.2, HISTONE H3, ... | | 著者 | White, C.L, Suto, R.K, Luger, K. | | 登録日 | 2001-04-03 | | 公開日 | 2001-09-28 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions.
EMBO J., 20, 2001
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7BQ9
 | | Crystal structure of ASFV p15 | | 分子名称: | 60 kDa polyprotein | | 著者 | Fu, D, Chen, C, Guo, Y. | | 登録日 | 2020-03-24 | | 公開日 | 2020-06-24 | | 実験手法 | X-RAY DIFFRACTION (2.612 Å) | | 主引用文献 | Structure of a bifunctional membrane-DNA binding protein, African swine fever virus p15
Protein Cell, 2020
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6W5C
 | | Cryo-EM structure of Cas12i(E894A)-crRNA-dsDNA complex | | 分子名称: | Cas12i, NTS, Substrate, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2020-03-13 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.
Nat.Struct.Mol.Biol., 27, 2020
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6X68
 | | Cryo-EM structure of piggyBac transposase synaptic complex with hairpin DNA (SNHP) | | 分子名称: | CALCIUM ION, Transposase, ZINC ION, ... | | 著者 | Chen, Q, Hickman, A.B, Dyda, F. | | 登録日 | 2020-05-27 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Structural basis of seamless excision and specific targeting by piggyBac transposase
Nat Commun, 11, 2020
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7NZM
 | | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yan, Y, Hardwick, S, Ron, D. | | 登録日 | 2021-03-24 | | 公開日 | 2021-09-29 | | 最終更新日 | 2021-10-20 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
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3DLH
 | | Crystal structure of the guide-strand-containing Argonaute protein silencing complex | | 分子名称: | ACETIC ACID, Argonaute, DNA (5'-D(DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DAP*DTP*DAP*DGP*DT)-3'), ... | | 著者 | Wang, Y, Sheng, G, Patel, D.J. | | 登録日 | 2008-06-27 | | 公開日 | 2008-09-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
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8D80
 | | Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3 | | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, DNA-binding protein Ikaros, ... | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2022-06-07 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
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5GT0
 | | Crystal structure of nucleosome complex with human testis-specific histone variants, Th2a | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-A, ... | | 著者 | Kumarevel, T, Sivaraman, P. | | 登録日 | 2016-08-18 | | 公開日 | 2017-02-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b
Biophys. Chem., 221, 2017
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7KLP
 | | Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex | | 分子名称: | HEXAETHYLENE GLYCOL, POTASSIUM ION, telomeric DNA | | 著者 | Yatsunyk, L.A, Li, K.S, Chen, E.V. | | 登録日 | 2020-10-30 | | 公開日 | 2020-12-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Water spines and networks in G-quadruplex structures.
Nucleic Acids Res., 49, 2021
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7LYC
 | | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) | | 分子名称: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | | 登録日 | 2021-03-06 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
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1CYQ
 | | INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX | | 分子名称: | 5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3', INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, MAGNESIUM ION, ... | | 著者 | Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L. | | 登録日 | 1999-08-31 | | 公開日 | 1999-11-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | A novel endonuclease mechanism directly visualized for I-PpoI.
Nat.Struct.Biol., 6, 1999
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3QQ6
 | | The N-terminal DNA binding domain of SinR from Bacillus subtilis | | 分子名称: | HTH-type transcriptional regulator sinR | | 著者 | Colledge, V, Fogg, M.J, Levdikov, V.M, Dodson, E.J, Wilkinson, A.J. | | 登録日 | 2011-02-15 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis.
J.Mol.Biol., 411, 2011
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4I2D
 | | Binary complex of mouse TdT with AMPcPP | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA nucleotidylexotransferase, MAGNESIUM ION, ... | | 著者 | Gouge, J, Delarue, M. | | 登録日 | 2012-11-21 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism.
J.Mol.Biol., 425, 2013
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5TN0
 | | Solution Structure of the N-terminal DNA-binding domain of the master biofilm-regulator SinR from Bacillus subtilis | | 分子名称: | HTH-type transcriptional regulator SinR | | 著者 | Draughn, G.L, Bobay, B.G, Stowe, S.D, Thompson, R.J, Cavanagh, J. | | 登録日 | 2016-10-13 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis.
J.Mol.Biol., 2019
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5XF5
 | | Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,S-configuration) | | 分子名称: | (1S,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | | 著者 | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | | 登録日 | 2017-04-07 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
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8MHT
 | | CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX | | 分子名称: | 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... | | 著者 | O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. | | 登録日 | 1998-08-06 | | 公開日 | 1998-11-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
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8QWE
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