7RWQ
 
 | | Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one | | 分子名称: | 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one, CALCIUM ION, Nucleosome-remodeling factor subunit BPTF | | 著者 | Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. | | 登録日 | 2021-08-20 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
J.Med.Chem., 64, 2021
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7RWO
 | | Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one | | 分子名称: | 1,2-ETHANEDIOL, 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF | | 著者 | Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. | | 登録日 | 2021-08-20 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
J.Med.Chem., 64, 2021
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3X1U
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7XCT
 | | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-25 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XCR
 | | Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-25 | | 公開日 | 2022-04-20 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XD0
 | | cryo-EM structure of H2BK34ub nucleosome | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-26 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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7XD1
 | | cryo-EM structure of unmodified nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. | | 登録日 | 2022-03-26 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Nat.Chem.Biol., 18, 2022
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5C8L
 | | Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NudF protein, ... | | 著者 | Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M. | | 登録日 | 2015-06-25 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
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5C7Q
 | | Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M. | | 登録日 | 2015-06-24 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
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6BUZ
 | | Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N | | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B, ... | | 著者 | Chittori, S, Hong, J, Kelly, A.E, Bai, Y, Subramaniam, S. | | 登録日 | 2017-12-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.
Science, 359, 2018
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6K2Q
 | | Aeromonas hydrophila MtaN-2 complexed with adenine | | 分子名称: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | | 著者 | Chen, J, Liu, W, Wang, L, Shang, F, Lan, J, Chen, Y, Xu, Y. | | 登録日 | 2019-05-15 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Aeromonas hydrophila Cytoplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase.
Biochemistry, 58, 2019
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5C7T
 | | Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase in complex with ADP-ribose | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5-DIPHOSPHORIBOSE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Gabelli, S.B, de la Pena, A.H, Suarez, A, Amzel, L.M. | | 登録日 | 2015-06-24 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
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7D69
 | | Cryo-EM structure of the nucleosome containing Giardia histones | | 分子名称: | 601L DNA (145-MER), Histone H2A, Histone H2B, ... | | 著者 | Sato, S, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2020-09-29 | | 公開日 | 2021-09-08 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones.
Nucleic Acids Res., 49, 2021
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4CDO
 | | Crystal structure of PQBP1 bound to spliceosomal U5-15kD | | 分子名称: | THIOREDOXIN-LIKE PROTEIN 4A, POLYGLUTAMINE-BINDING PROTEIN | | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Nabeshima, Y, Okazawa, H. | | 登録日 | 2013-11-05 | | 公開日 | 2014-04-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd.
Nat.Commun., 5, 2014
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3X1T
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3X1V
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6KSW
 | | Cryo-EM structure of the human concentrative nucleoside transporter CNT3 | | 分子名称: | Solute carrier family 28 member 3 | | 著者 | Zhou, Y.X, Liao, L.H, Li, J.L, Xiao, Q.J, Sun, L.F, Deng, D. | | 登録日 | 2019-08-26 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of the human concentrative nucleoside transporter CNT3.
Plos Biol., 18, 2020
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3X1S
 | | Crystal structure of the nucleosome core particle | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | | 著者 | Sivaraman, P, Kumarevel, T.S. | | 登録日 | 2014-11-27 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming
Biochem.Biophys.Res.Commun., 464, 2015
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1AOI
 | | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT | | 分子名称: | HISTONE H2A, HISTONE H2B, HISTONE H3, ... | | 著者 | Luger, K, Maeder, A.W, Richmond, R.K, Sargent, D.F, Richmond, T.J. | | 登録日 | 1997-07-03 | | 公開日 | 1998-09-30 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the nucleosome core particle at 2.8 A resolution.
Nature, 389, 1997
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5BSK
 | | Human HGPRT in complex with (S)-HPEPG, an acyclic nucleoside phosphonate | | 分子名称: | (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | | 著者 | Keough, D.T, Guddat, L.W, Kaiser, M.M, Hockova, D, Wang, T.-H, Janeba, Z. | | 登録日 | 2015-06-02 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
Chemmedchem, 10, 2015
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6UIW
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6UIV
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6UIX
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6SHU
 | | Borrelia burgdorferi BmpD nucleoside binding protein bound to adenosine | | 分子名称: | ADENOSINE, Basic membrane protein D, CHLORIDE ION, ... | | 著者 | Guedez, G, Astrand, M, Cuellar, J, Hytonen, J, Salminen, T.A. | | 登録日 | 2019-08-08 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.43002868 Å) | | 主引用文献 | Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.
Infect.Immun., 88, 2020
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6VAK
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