PDB: 237423 件ウェブページステータス検索Chemie searchBIRD

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6DBL	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Molecule name: Forward strand of 12-RSS substrate DNA, Molecule name: Forward strand of 23-RSS substrate DNA, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBM	Tyk2 with compound 23 分子名称: Non-receptor tyrosine-protein kinase TYK2, [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone 著者 Vajdos, F.F. 登録日 2018-05-03 公開日 2018-08-29 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.368 Å) 主引用文献 Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
6DBN	Jak1 with compound 23 分子名称: Tyrosine-protein kinase JAK1, [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone 著者 Vajdos, F.F. 登録日 2018-05-03 公開日 2018-08-29 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
6DBO	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Forward strand of substrate RSS DNA, Recombination activating gene 1 - MBP chimera, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBP	RNA-recognition motif 1 of human MSI2 分子名称: RNA-binding protein Musashi homolog 2 著者 Goldgur, Y, Kharas, M.G, Minuesa, G. 登録日 2018-05-03 公開日 2019-05-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun, 10, 2019
6DBQ	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Molecule name: Forward strand of 12-RSS substrate DNA, Molecule name: Forward strand of 23-RSS substrate DNA, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.22 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBR	Cryo-EM structure of RAG in complex with one melted RSS and one unmelted RSS 分子名称: CALCIUM ION, Forward strand of melted RSS substrate DNA, Forward strand of unmelted RSS substrate DNA, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBS	Fusion surface structure, function, and dynamics of gamete fusogen HAP2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hapless 2, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Feng, J, Dong, X, Springer, T.A. 登録日 2018-05-03 公開日 2018-09-19 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife, 7, 2018
6DBT	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Forward strand of 12-RSS substrate DNA, Forward strand of 23-RSS substrate DNA, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBU	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Forward strand RSS substrate DNA, Recombination activating gene 1 - MBP chimera, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBV	Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs 分子名称: CALCIUM ION, Forward strand of 12-RSS substrate DNA, Forward strand of 23-RSS substrate DNA, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (4.29 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBW	Cryo-EM structure of RAG in complex with 12-RSS substrate DNA 分子名称: CALCIUM ION, Forward strand of 12-RSS substrate DNA, Recombination activating gene 1 - MBP chimera, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBX	Cryo-EM structure of RAG in complex with 12-RSS substrate DNA 分子名称: CALCIUM ION, Forward strand of 12-RSS substrate DNA, Recombination activating gene 1 - MBP chimera, ... 著者 Wu, H, Liao, M, Ru, H, Mi, W. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
6DBY	Crystal structure of Nudix 1 from Arabidopsis thaliana 分子名称: MAGNESIUM ION, Nudix hydrolase 1 著者 Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. 登録日 2018-05-03 公開日 2018-09-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
6DBZ	Crystal structure of Nudix 1 from Arabidopsis thaliana complexed with isopentenyl diphosphate 分子名称: ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, Nudix hydrolase 1 著者 Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. 登録日 2018-05-03 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
6DC0	Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron 分子名称: Tribbles homolog 1,CCAAT/enhancer-binding protein alpha 著者 Jamieson, S.A, Brewster, J.L, Mace, P.D. 登録日 2018-05-03 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Sci Signal, 11, 2018
6DC1	Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-nitro-2-oxidanyl-benzenecarbonitrile, ... 著者 Jackson, C.J, Hong, N.-S, Carr, P.D. 登録日 2018-05-03 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9, 2018
6DC2	Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase C301S variant 分子名称: Carbon monoxide dehydrogenase, FE (III) ION, FE(4)-NI(1)-S(4) CLUSTER, ... 著者 Wittenborn, E.C, Drennan, C.L. 登録日 2018-05-04 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife, 7, 2018
6DC3	RSV prefusion F bound to RSD5 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab RSD5-Germline Heavy Chain, Fab RSD5-Germline Light Chain, ... 著者 Battles, M.B, McLellan, J.S, Jones, H.J. 登録日 2018-05-04 公開日 2019-07-10 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
6DC4	RSV-neutralizing human antibody AM22 分子名称: 1,2-ETHANEDIOL, Fab AM22 Heavy Chain, Fab AM22 Light Chain 著者 Jones, H.G, McLellan, J.S. 登録日 2018-05-04 公開日 2019-07-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
6DC5	RSV prefusion F in complex with AM22 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Jones, H.G, McLellan, J.S. 登録日 2018-05-04 公開日 2019-07-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
6DC6	Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin 分子名称: MAGNESIUM ION, PYROPHOSPHATE 2-, Ubiquitin, ... 著者 Lv, Z, Yuan, L, Williams, K.M, Atkison, J.H, Olsen, S.K. 登録日 2018-05-04 公開日 2018-10-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J. Biol. Chem., 293, 2018
6DC7	Apo Fab structure of mouse monoclonal antibody 8B2 分子名称: Fab heavy chain, Fab light chain 著者 Chukwu, J.E, Kong, X.-P. 登録日 2018-05-04 公開日 2019-03-20 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein. MAbs, 11, 2019
6DC8	Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope. 分子名称: GLYCEROL, IgG heavy chain, IgG light chain, ... 著者 Chukwu, J.E, Kong, X.-P. 登録日 2018-05-04 公開日 2019-03-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein. MAbs, 11, 2019
6DC9	Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. 分子名称: Fab heavy chain, Fab light chain, GLYCEROL, ... 著者 Chukwu, J.E, Kong, X.-P. 登録日 2018-05-04 公開日 2019-03-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.999 Å) 主引用文献 Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein. MAbs, 11, 2019

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