PDB: 20505 件ウェブページステータス検索Chemie searchBIRD

---

7RUT	Structure of Human ATP:Cobalamin Adenosyltransferase R190C bound to ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Corrinoid adenosyltransferase, GLYCEROL, ... 著者 Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. 登録日 2021-08-18 公開日 2021-11-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. J.Biol.Chem., 297, 2021
7RUV	Structure of Human ATP:Cobalamin Adenosyltransferase E193K bound to adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, COBALAMIN, Corrinoid adenosyltransferase, ... 著者 Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. 登録日 2021-08-18 公開日 2021-11-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. J.Biol.Chem., 297, 2021
7SEA	Crystal structure of human Fibrillarin in complex with compound 2 from cocktail soak 分子名称: 6-(trifluoromethyl)pyrimidin-4-amine, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SE7	Crystal structure of human Fibrillarin in complex with S-adenosyl-L-methionine 分子名称: S-ADENOSYLMETHIONINE, rRNA 2'-O-methyltransferase fibrillarin 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SED	Crystal structure of human Fibrillarin in complex with compound 2a 分子名称: FORMIC ACID, N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidin-4-amine, rRNA 2'-O-methyltransferase fibrillarin 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SEC	Crystal structure of human Fibrillarin in complex with compound 1a 分子名称: 2-[(8S)-4-oxo-2-(trifluoromethyl)-4,5-dihydropyrazolo[1,5-a]pyrazin-6-yl]acetamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SE6	Crystal structure of human Fibrillarin in ligand-free state 分子名称: FORMIC ACID, rRNA 2'-O-methyltransferase fibrillarin 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SEB	Crystal structure of human Fibrillarin in complex with compound 2 from single soak 分子名称: 6-(trifluoromethyl)pyrimidin-4-amine, FORMIC ACID, rRNA 2'-O-methyltransferase fibrillarin 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SE8	Crystal structure of human Fibrillarin in complex with fragment 1 from cocktail soak 分子名称: (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SE9	Crystal structure of human Fibrillarin in complex with compound 1 from single soak 分子名称: (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. 登録日 2021-09-30 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
7SLQ	Cryo-EM structure of 7SK core RNP with circular RNA 分子名称: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Minimal circular 7SK RNA, ... 著者 Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. 登録日 2021-10-24 公開日 2022-03-30 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
7SLP	Cryo-EM structure of 7SK core RNP with linear RNA 分子名称: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Linear 7SK RNA, ... 著者 Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. 登録日 2021-10-24 公開日 2022-03-30 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
7SCX	KRAS full-length G12V in complex with RGL1 Ras association domain 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. 登録日 2021-09-29 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
7S7J	Structure of Human SPASTIN-IST1 complex. 分子名称: CALCIUM ION, CHLORIDE ION, IST1 homolog, ... 著者 Skalicky, J.J, Sundquist, W.I. 登録日 2021-09-16 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. Elife, 11, 2022
4YEG	Characterisation of Polyphosphate Kinase 2 from the Intracellular Pathogen Francisella tularensis 分子名称: Polyphosphate kinase 2 著者 Parnell, A.E, Roach, P.L. 登録日 2015-02-24 公開日 2015-12-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Biochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis. Biosci.Rep., 36, 2016
4X8M	Crystal structure of E. coli Adenylate kinase Y171W mutant 分子名称: Adenylate kinase 著者 Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. 登録日 2014-12-10 公開日 2015-07-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for catalytically restrictive dynamics of a high-energy enzyme state. Nat Commun, 6, 2015
4X8O	Crystal structure of E. coli Adenylate kinase Y171W mutant in complex with inhibitor Ap5a 分子名称: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... 著者 Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. 登録日 2014-12-10 公開日 2015-07-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for catalytically restrictive dynamics of a high-energy enzyme state. Nat Commun, 6, 2015
5F8A	Crystal structure of the ternary EcoRV-DNA-Lu complex with uncleaved DNA substrate. Lanthanide binding to EcoRV-DNA complex inhibits cleavage. 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*T)-3'), LUTETIUM (III) ION, ... 著者 Sangani, S.S, Kehr, A.D, Sinha, K, Rule, G.S, Jen-Jacobson, L. 登録日 2015-12-09 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein-DNA Complex. Biochemistry, 55, 2016
4X5X	HLA-DR1 mutant bN82A with covalently linked CLIP106-120(M107W) 分子名称: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain 著者 Guenther, S, Freund, C. 登録日 2014-12-06 公開日 2016-03-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.199 Å) 主引用文献 MHC class II complexes sample intermediate states along the peptide exchange pathway. Nat Commun, 7, 2016
4X8L	Crystal structure of E. coli Adenylate kinase P177A mutant in complex with inhibitor Ap5a 分子名称: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... 著者 Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. 登録日 2014-12-10 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for catalytically restrictive dynamics of a high-energy enzyme state. Nat Commun, 6, 2015
4X8H	Crystal structure of E. coli Adenylate kinase P177A mutant 分子名称: Adenylate kinase 著者 Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. 登録日 2014-12-10 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for catalytically restrictive dynamics of a high-energy enzyme state. Nat Commun, 6, 2015
5EKI	Crystal Structure of Truncated CCL21 分子名称: C-C motif chemokine 21, SULFATE ION 著者 Lewandowski, E.M, Smith, E.W, Chen, Y. 登録日 2015-11-03 公開日 2016-10-05 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic Structure of Truncated CCL21 and the Putative Sulfotyrosine-Binding Site. Biochemistry, 55, 2016
4YN6	Structural Insight reveals dynamics in repeating r(CAG) transcript found in Huntington's disease (HD) and Spinocerebellar ataxias (SCAs) 分子名称: PHOSPHATE ION, RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 著者 Tawani, A, Kumar, A. 登録日 2015-03-09 公開日 2015-04-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs) Plos One, 10, 2015
4Z22	structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor DR718A 分子名称: 2-amino-7-phenyl-3-{[(2R,5S)-5-phenyltetrahydrofuran-2-yl]methyl}quinazolin-4(3H)-one, Plasmepsin-2 著者 Recacha, R, Leitans, J, Tars, K, Jaudzems, K. 登録日 2015-03-28 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. J.Med.Chem., 59, 2016
4ZBF	Mcl-1 complexed with small molecules 分子名称: (1R)-7-[3-(naphthalen-1-yloxy)propyl]-3,4-dihydro-2H-[1,4]thiazepino[2,3,4-hi]indole-6-carboxylic acid 1-oxide, Induced myeloid leukemia cell differentiation protein Mcl-1 著者 Zhao, B. 登録日 2015-04-14 公開日 2015-04-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58, 2015

<579580581582583584585586587588589590591592593594>