7L3K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3k by Molmil](/molmil-images/mine/7l3k) | T4 Lysozyme L99A - benzylacetate - cryo | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Fischer, M, Bradford, S.Y.C. | 登録日 | 2020-12-17 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | 主引用文献 | Temperature artifacts in protein structures bias ligand-binding predictions. Chem Sci, 12, 2021
|
|
7L3C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3c by Molmil](/molmil-images/mine/7l3c) | T4 Lysozyme L99A - o-xylene - RT | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Fischer, M, Bradford, S.Y.C. | 登録日 | 2020-12-17 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Temperature artifacts in protein structures bias ligand-binding predictions. Chem Sci, 12, 2021
|
|
7L3E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3e by Molmil](/molmil-images/mine/7l3e) | T4 Lysozyme L99A - 3-iodotoluene - cryo | 分子名称: | 1-iodo-3-methylbenzene, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, ... | 著者 | Fischer, M, Bradford, S.Y.C. | 登録日 | 2020-12-17 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Temperature artifacts in protein structures bias ligand-binding predictions. Chem Sci, 12, 2021
|
|
7L3D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3d by Molmil](/molmil-images/mine/7l3d) | T4 Lysozyme L99A - 3-iodotoluene - RT | 分子名称: | 1-iodo-3-methylbenzene, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, ... | 著者 | Fischer, M, Bradford, S.Y.C. | 登録日 | 2020-12-17 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Temperature artifacts in protein structures bias ligand-binding predictions. Chem Sci, 12, 2021
|
|
7L3I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3i by Molmil](/molmil-images/mine/7l3i) | |
5EE7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ee7 by Molmil](/molmil-images/mine/5ee7) | Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, Glucagon receptor,Endolysin,Glucagon receptor, ... | 著者 | Jazayeri, A, Dore, A.S, Lamb, D, Krishnamurthy, H, Southall, S.M, Baig, A.H, Bortolato, A, Koglin, M, Robertson, N.J, Errey, J.C, Andrews, S.P, Brown, A.J.H, Cooke, R.M, Weir, M, Marshall, F.H. | 登録日 | 2015-10-22 | 公開日 | 2016-04-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Extra-helical binding site of a glucagon receptor antagonist. Nature, 533, 2016
|
|
5CGD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cgd by Molmil](/molmil-images/mine/5cgd) | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242) | 分子名称: | 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID | 著者 | Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M. | 登録日 | 2015-07-09 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58, 2015
|
|
5CGC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cgc by Molmil](/molmil-images/mine/5cgc) | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, ... | 著者 | Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M. | 登録日 | 2015-07-09 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | 主引用文献 | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58, 2015
|
|
3V2Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3v2y by Molmil](/molmil-images/mine/3v2y) | Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingosine 1-phosphate receptor 1, Lysozyme chimera (E.C.3.2.1.17), ... | 著者 | Hanson, M.A, Roth, C.B, Jo, E, Griffith, M.T, Scott, F.L, Reinhart, G, Desale, H, Clemons, B, Cahalan, S.M, Schuerer, S.C, Sanna, M.G, Han, G.W, Kuhn, P, Rosen, H, Stevens, R.C, GPCR Network (GPCR) | 登録日 | 2011-12-12 | 公開日 | 2012-02-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of a lipid G protein-coupled receptor. Science, 335, 2012
|
|
5EUT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eut by Molmil](/molmil-images/mine/5eut) | |
4TN3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4tn3 by Molmil](/molmil-images/mine/4tn3) | Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha | 分子名称: | TRIM5/cyclophilin A fusion protein/T4 Lysozyme chimera, ZINC ION | 著者 | Kirkpatrick, J.J, Stoye, J.P, Taylor, I.A, Goldstone, D.C. | 登録日 | 2014-06-03 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.1989 Å) | 主引用文献 | Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
7SJ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sj6 by Molmil](/molmil-images/mine/7sj6) | T4 Lysozyme L99A/M102H with 1,2-Azaborine bound | 分子名称: | 1,2-dihydro-1,2-azaborinine, 2-HYDROXYETHYL DISULFIDE, ACETATE ION, ... | 著者 | Yao, L, Wirth, J. | 登録日 | 2021-10-16 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | T4 Lysozyme L99A/M102H with 1,2-Azaborine bound to be published
|
|
7RX9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rx9 by Molmil](/molmil-images/mine/7rx9) | Structure of autoinhibited P-Rex1 | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION | 著者 | Ellisdon, A.M, Chang, Y. | 登録日 | 2021-08-22 | 公開日 | 2022-08-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
|
|
8DCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8dcs by Molmil](/molmil-images/mine/8dcs) | Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | 分子名称: | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
|
|
8DCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8dcr by Molmil](/molmil-images/mine/8dcr) | Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | 分子名称: | DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
|
|
4IAP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iap by Molmil](/molmil-images/mine/4iap) | |
5XSZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xsz by Molmil](/molmil-images/mine/5xsz) | Crystal structure of zebrafish lysophosphatidic acid receptor LPA6 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lysophosphatidic acid receptor 6a,Endolysin,Lysophosphatidic acid receptor 6a | 著者 | Taniguchi, R, Nishizawa, T, Ishitani, R, Nureki, O. | 登録日 | 2017-06-16 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6 Nature, 548, 2017
|
|
4WTV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wtv by Molmil](/molmil-images/mine/4wtv) | Crystal structure of the phosphatidylinositol 4-kinase IIbeta | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-beta,Endolysin,Phosphatidylinositol 4-kinase type 2-beta | 著者 | Klima, M, Baumlova, A, Chalupska, D, Boura, E. | 登録日 | 2014-10-30 | 公開日 | 2015-07-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. Acta Crystallogr.,Sect.D, 71, 2015
|
|
6IIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6iih by Molmil](/molmil-images/mine/6iih) | crystal structure of mitochondrial calcium uptake 2(MICU2) | 分子名称: | CALCIUM ION, Endolysin,Calcium uptake protein 2, mitochondrial | 著者 | Shen, Q, Wu, W, Zheng, J, Jia, Z. | 登録日 | 2018-10-06 | 公開日 | 2019-08-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.958 Å) | 主引用文献 | The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation. Embo Rep., 20, 2019
|
|
4XES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xes by Molmil](/molmil-images/mine/4xes) | Structure of active-like neurotensin receptor | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Krumm, B.E, White, J.F, Shah, P, Grisshammer, R. | 登録日 | 2014-12-24 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural prerequisites for G-protein activation by the neurotensin receptor. Nat Commun, 6, 2015
|
|
5JDT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jdt by Molmil](/molmil-images/mine/5jdt) | Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K | 分子名称: | AZIDE ION, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Loll, B, Consentius, P, Gohlke, U, Mueller, R, Kaupp, M, Heinemann, U, Wahl, M.C, Risse, T. | 登録日 | 2016-04-17 | 公開日 | 2016-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Tracking Transient Conformational States of T4 Lysozyme at Room Temperature Combining X-ray Crystallography and Site-Directed Spin Labeling. J.Am.Chem.Soc., 138, 2016
|
|
5JGV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jgv by Molmil](/molmil-images/mine/5jgv) | Spin-Labeled T4 Lysozyme Construct A73V1 | 分子名称: | CHLORIDE ION, Endolysin, HEXANE-1,6-DIOL, ... | 著者 | Balo, A.R, Feyrer, H, Ernst, O.P. | 登録日 | 2016-04-20 | 公開日 | 2017-02-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | 主引用文献 | Toward Precise Interpretation of DEER-Based Distance Distributions: Insights from Structural Characterization of V1 Spin-Labeled Side Chains. Biochemistry, 55, 2016
|
|
4XEE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xee by Molmil](/molmil-images/mine/4xee) | Structure of active-like neurotensin receptor | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Krumm, B.E, White, J.F, Shah, P, Grisshammer, R. | 登録日 | 2014-12-23 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural prerequisites for G-protein activation by the neurotensin receptor. Nat Commun, 6, 2015
|
|
5JGU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jgu by Molmil](/molmil-images/mine/5jgu) | Spin-Labeled T4 Lysozyme Construct R119V1 | 分子名称: | CHLORIDE ION, Endolysin, PHOSPHATE ION, ... | 著者 | Balo, A.R, Feyrer, H, Ernst, O.P. | 登録日 | 2016-04-20 | 公開日 | 2017-02-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.468 Å) | 主引用文献 | Toward Precise Interpretation of DEER-Based Distance Distributions: Insights from Structural Characterization of V1 Spin-Labeled Side Chains. Biochemistry, 55, 2016
|
|
5JGN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jgn by Molmil](/molmil-images/mine/5jgn) | Spin-Labeled T4 Lysozyme Construct I9V1 | 分子名称: | CHLORIDE ION, Endolysin, PHOSPHATE ION, ... | 著者 | Balo, A.R, Feyrer, H, Ernst, O.P. | 登録日 | 2016-04-20 | 公開日 | 2017-02-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.534 Å) | 主引用文献 | Toward Precise Interpretation of DEER-Based Distance Distributions: Insights from Structural Characterization of V1 Spin-Labeled Side Chains. Biochemistry, 55, 2016
|
|