Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha

Summary for 4TN3

DescriptorTRIM5/cyclophilin A fusion protein/T4 Lysozyme chimera, ZINC ION (2 entities in total)
Functional Keywordstrim protein coiled-coil scaffold retroviral restriction factor, antiviral protein
Biological sourceMacaca mulatta (Rhesus macaque)
Total number of polymer chains2
Total molecular weight92931.19
Kirkpatrick, J.J.,Stoye, J.P.,Taylor, I.A.,Goldstone, D.C. (deposition date: 2014-06-03, release date: 2014-07-16, Last modification date: 2020-01-08)
Primary citation
Goldstone, D.C.,Walker, P.A.,Calder, L.J.,Coombs, P.J.,Kirkpatrick, J.,Ball, N.J.,Hilditch, L.,Yap, M.W.,Rosenthal, P.B.,Stoye, J.P.,Taylor, I.A.
Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
Proc.Natl.Acad.Sci.USA, 111:9609-9614, 2014
PubMed: 24979782 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1402448111
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.32521.0%4.4%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-07-29