PDB: 217686 件ウェブページステータス検索Chemie searchBIRD

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8AHH	PAC FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery 分子名称: 5-cyano-~{N}-methyl-pyrazolo[1,5-a]pyridine-3-carboxamide, Serine/threonine-protein kinase PAK 4 著者 Baker, L.M, Murray, J.B, Hubbard, R.E. 登録日 2022-07-21 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.037 Å) 主引用文献 PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery. Rsc Med Chem, 13, 2022
8AHG	PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery 分子名称: Serine/threonine-protein kinase PAK 4, ~{N}-methyl-3-propan-2-yl-1~{H}-pyrazolo[3,4-c]pyridine-4-carboxamide 著者 Baker, L.M, Murray, J.B, Hubbard, R.E. 登録日 2022-07-21 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery. Rsc Med Chem, 13, 2022
6UVU	Crystal structure of the AntR antimony-specific transcriptional repressor 分子名称: ArsR family transcriptional regulator 著者 Thiruselvam, V, Banumathi, S, Palani, K, Manohar, R, Rosen, B.P. 登録日 2019-11-04 公開日 2020-11-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Functional and structural characterization of AntR, an Sb(III) responsive transcriptional repressor. Mol.Microbiol., 116, 2021
6UW0	Engineered variant of I-OnuI meganuclease with improved thermostability and fully altered specificity targeting cholera toxin A subunit 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ... 著者 Werther, R, Stoddard, B.L. 登録日 2019-11-04 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition. Structure, 28, 2020
8AHI	PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery 分子名称: Serine/threonine-protein kinase PAK 4, ~{N}-methyl-1,3-benzothiazole-6-carboxamide 著者 Baker, L.M, Murray, J.B, Hubbard, R.E. 登録日 2022-07-21 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery. Rsc Med Chem, 13, 2022
4XLR	Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA 分子名称: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
8CZ8	Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics 分子名称: Mesothelin, cleaved form, SULFATE ION, ... 著者 Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. 登録日 2022-05-24 公開日 2023-06-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
5LDA	Structure of deubiquitinating enzyme homolog (Pyrococcus furiosus JAMM1) in complex with ubiquitin-like SAMP2. 分子名称: GLYCEROL, JAMM1, SAMP2, ... 著者 Cao, S, Engilberge, S, Girard, E, Gabel, F, Franzetti, B, Maupin-Furlow, J.A. 登録日 2016-06-24 公開日 2017-06-21 最終更新日 2022-03-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN(+) Proteases. Structure, 25, 2017
8ZHE	SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-10 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
4XOJ	Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1) 分子名称: 1,2-ETHANEDIOL, AMMONIUM ION, CALCIUM ION, ... 著者 Golik, P, Malicki, S, Grudnik, P, Karna, N, Debowski, D, Legowska, A, Wladyka, B, Gitlin, A, Brzozowski, K, Dubin, G, Rolka, K. 登録日 2015-01-16 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (0.91 Å) 主引用文献 Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1). Chembiochem, 16, 2015
8ZHH	SARS-CoV-2 spike trimer (6P) in complex with two H18 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-10 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (5.55 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
7SZR	NIK bound to inhibitor G02792917 分子名称: 1-(3-{[(1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2-azabicyclo[3.1.0]hexan-4-yl]ethynyl}phenyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION 著者 Liau, N.P.D, Hymowitz, S.G. 登録日 2021-11-29 公開日 2023-06-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design. Bioorg.Med.Chem.Lett., 89, 2023
8ZHM	SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
6STZ	Crystal structure of dimethylated RSLex - cucurbituril free form 分子名称: Fucose-binding lectin protein, beta-D-fructopyranose 著者 Guagnini, F, Engilberge, S, Crowley, P.B. 登録日 2019-09-12 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Engineered assembly of a protein-cucurbituril biohybrid. Chem.Commun.(Camb.), 56, 2020
4XE9	Crystal structure of the NanB sialidase from Streptococcus pneumoniae in complex with Optactin 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B 著者 Brear, P. 登録日 2014-12-23 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XES	Structure of active-like neurotensin receptor 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Krumm, B.E, White, J.F, Shah, P, Grisshammer, R. 登録日 2014-12-24 公開日 2015-07-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural prerequisites for G-protein activation by the neurotensin receptor. Nat Commun, 6, 2015
5LMG	Structure of C-terminal domain from S. cerevisiae Pat1 decapping activator bound to Dcp2 HLM10 peptide (region 954-970) 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA topoisomerase 2-associated protein PAT1, ... 著者 Charenton, C, Gaudon-Plesse, C, Fourati, Z, Taverniti, V, Back, R, Kolesnikova, O, Seraphin, B, Graille, M. 登録日 2016-07-30 公開日 2017-08-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8FCI	tRNA (N1G37) Methyltransferase (TrmD) of Mycobacterium avium complexed with S-Adenosyl homocysteine 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(1)-)-methyltransferase 著者 Lavallee, T, Mehta, K, Young, A, Cortes, J, Isaacson, B, Brylewski, J, Schlegel, F, Doti, L, Battaile, K, Stojanoff, V, Perez, A, Bolen, R. 登録日 2022-12-01 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 tRNA (N1G37) Methyltransferase (TrmD) of Mycobacterium avium complexed with S-Adenosyl homocysteine To Be Published
6VB3	HLA-B*15:01 complexed with a synthetic peptide 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... 著者 Schutte, R.J, Li, D, Ostrov, D.A. 登録日 2019-12-18 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 HLA-B*15:01 complexed with a synthetic peptide To Be Published
4XLN	Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA 分子名称: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
8FNX	Crystal structure of Hyaluronate lyase B from Cutibacterium acnes 分子名称: GLYCEROL, Hyaluronate lyase, PHOSPHATE ION 著者 Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. 登録日 2022-12-28 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
8FCH	Apo Structure of (N1G37) Methyltransferase from Mycobacterium avium 分子名称: tRNA (guanine-N(1)-)-methyltransferase 著者 Isaacson, B, Brylewski, J, Schlegel, F, Cortes, J, Lavallee, T, Mehta, K, Young, A, Doti, L, Battaile, K.P, Stojanoff, V, Perez, A, Bolen, R. 登録日 2022-12-01 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.956 Å) 主引用文献 Apo structure of (N1G37) Methyltransferase from Mycobacterium avium. To Be Published
6SZV	Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) 分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2019-10-02 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
6VB2	HLA-B*15:02 complexed with a synthetic peptide 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... 著者 Schutte, R.J, Li, D, Ostrov, D.A. 登録日 2019-12-18 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 HLA-B*15:02 complexed with a synthetic peptide To Be Published
8FHC	Protein 41 with aldehyde deformylating oxidase activity from Gamma proteobacterium 分子名称: BROMIDE ION, CHOLIC ACID, FE (III) ION, ... 著者 Arenas, R, Wilson, D.K, Mak, W.S, Siegel, J.B. 登録日 2022-12-13 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Protein 41 with aldehyde deformylating oxidase activity from Gamma proteobacterium To Be Published

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