PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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4U6Z	HsMetAP(F309M) in complex with 1-amino-2-propylpentyl)phosphonic acid 分子名称: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-30 公開日 2015-04-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
6D8F	RsAgo Ternary Complex with Guide RNA and Target DNA Containing T-T Bulge Within the Seed Segment 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*TP*TP*AP*AP*C)-3'), ... 著者 Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J. 登録日 2018-04-26 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA. Cell Rep, 24, 2018
4TX9	Crystal structure of HisAp from Streptomyces sviceus with degraded ProFAR 分子名称: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Phosphoribosyl isomerase A, SULFATE ION 著者 Michalska, K, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-07-02 公開日 2014-08-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
4TXP	Crystal structure of LIP5 N-terminal domain 分子名称: Vacuolar protein sorting-associated protein VTA1 homolog 著者 Vild, C.J, Xu, Z. 登録日 2014-07-04 公開日 2015-02-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 A Novel Mechanism of Regulating the ATPase VPS4 by Its Cofactor LIP5 and the Endosomal Sorting Complex Required for Transport (ESCRT)-III Protein CHMP5. J.Biol.Chem., 290, 2015
4TXS	An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline 分子名称: (4-hydroxyphenyl)acetonitrile, Polyprotein 著者 Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. 登録日 2014-07-07 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
4TYG	Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase 分子名称: ACETATE ION, Fibroblast growth factor receptor 4 著者 Lesca, E, Lammens, A, Huber, R, Augustin, M. 登録日 2014-07-08 公開日 2014-09-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
4TYQ	Crystal structure of an adenylate kinase mutant--AKm2 分子名称: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, CALCIUM ION, ... 著者 Moon, S, Bae, E. 登録日 2014-07-09 公開日 2014-11-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structures of thermally stable adenylate kinase mutants designed by local structural entropy optimization and structure-guided mutagenesis J KOREAN SOC APPL BIOL CHEM, 57, 2014
4U67	Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 分子名称: 23s RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Wekselman, I, Zimmerman, E, Rozenberg, H, Bashan, A, Yonath, A. 登録日 2014-07-28 公開日 2015-08-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel. Structure, 25, 2017
4U9Y	Structure of the alpha-tubulin acetyltransferase alpha-TAT1/Mec-17 in complex with CoA 分子名称: Alpha-tubulin N-acetyltransferase 1, BROMIDE ION, COENZYME A 著者 Yuzawa, S, Sumimoto, H. 登録日 2014-08-07 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.201 Å) 主引用文献 Structure of the alpha-tubulin acetyltransferase alpha-TAT1/Mec-17 in complex with CoA To Be Published
4UA6	CTX-M-14 Class A Beta-Lactamase Apo Crystal Structure at 0.79 Angstrom Resolution 分子名称: Beta-lactamase CTX-M-14, PHOSPHATE ION, POTASSIUM ION 著者 Nichols, D.A, Chen, Y. 登録日 2014-08-08 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (0.79 Å) 主引用文献 Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography. J.Am.Chem.Soc., 137, 2015
4UFU	Crystal structure of human tankyrase 2 in complex with TA-12 分子名称: 8-methyl-2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Haikarainen, T, Lehtio, L. 登録日 2015-03-19 公開日 2016-04-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
4TVA	Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of TthPheRS with Puromycine 分子名称: PHENYLALANINE, PUROMYCIN, Phenylalanine--tRNA ligase alpha subunit, ... 著者 Safro, M, Klipcan, L, Tworowski, D, Peretz, M. 登録日 2014-06-26 公開日 2015-03-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin. Proc.Natl.Acad.Sci.USA, 112, 2015
4TWR	Structure of UDP-glucose 4-epimerase from Brucella abortus 分子名称: NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION 著者 Horanyi, P.S, Abendroth, J, Lorimer, D, Edwards, T, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2014-07-01 公開日 2014-10-08 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of UDP-glucose 4-epimerase from Brucella melitensis To Be Published
4TX6	AfChiA1 in complex with compound 1 分子名称: 3-(2-methoxyphenyl)-6-methyl[1,2]oxazolo[5,4-d]pyrimidin-4(5H)-one, Class III chitinase ChiA1, PHOSPHATE ION 著者 van Aalten, D.M.F. 登録日 2014-07-02 公開日 2014-08-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors FEBS Lett, 588, 2014
4TY8	An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline 分子名称: 6-methyl-2H-chromen-2-one, Polyprotein 著者 Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. 登録日 2014-07-08 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
4TYT	Crystal Structure of BcII metallo-beta-lactamase in complex with ML302F 分子名称: (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, Beta-lactamase 2, GLYCEROL, ... 著者 Brem, J, van Berkel, S.S, McDonough, M.A, Schofield, C.J. 登録日 2014-07-09 公開日 2014-11-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. Nat.Chem., 6, 2014
4U2C	Crystal structure of dienelactone hydrolase A-6 variant (S7T, A24V, Q35H, F38L, Q110L, C123S, Y145C, E199G and S208G) at 1.95 A resolution 分子名称: Carboxymethylenebutenolidase, SULFATE ION 著者 Porter, J.L, Collyer, C.A, Ollis, D.L. 登録日 2014-07-16 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
4U2D	Crystal structure of dienelactone hydrolase S-2 variant (Q35H, F38L, Q110L, C123S, Y137C, Y145C, N154D, E199G, S208G and G211D) at 1.67 A resolution 分子名称: Carboxymethylenebutenolidase, SULFATE ION 著者 Porter, J.L, Collyer, C.A, Ollis, D.L. 登録日 2014-07-16 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
4U2G	Crystal structure of dienelactone hydrolase B-4 variant (Q35H, F38L, Y64H, Q76L, Q110L, C123S, Y137C, A141V, Y145C, N154D, E199G, S208G, G211D, S233G and 237Q) at 1.80 A resolution 分子名称: Carboxymethylenebutenolidase, SULFATE ION 著者 Porter, J.L, Collyer, C.A, Ollis, D.L. 登録日 2014-07-16 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
4U2H	The crystal structure of apo CalE6, a methionine gamma lyase from Micromonospora echinospora 分子名称: CalE6, SULFATE ION 著者 Song, H.G, Xu, R. 登録日 2014-07-17 公開日 2015-01-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora Chembiochem, 16, 2015
4TV8	Tubulin-Maytansine complex 分子名称: (3beta,4beta,5beta,10beta,11E,13E)-maytansine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. 登録日 2014-06-26 公開日 2014-08-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111, 2014
4TWJ	The structure of Sir2Af2 bound to a myristoylated histone peptide 分子名称: ACETATE ION, GLYCEROL, Histone H4 peptide, ... 著者 Ringel, A.E, Roman, C, Wolberger, C. 登録日 2014-06-30 公開日 2014-12-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci., 23, 2014
4TX1	The crystal structure of carbohydrate acetylesterase family member from Sinorhizobium meliloti 分子名称: Esterase 著者 Kim, K, Kim, S.S, Pandian, R, Ngo, T.D. 登録日 2014-07-02 公開日 2014-12-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and biochemical characterization of a carbohydrate acetylesterase from Sinorhizobium meliloti 1021. Febs Lett., 589, 2015
4TYI	Structural analysis of the human Fibroblast Growth Factor Receptor 4 分子名称: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, Fibroblast growth factor receptor 4 著者 Lesca, E, Lammens, A, Huber, R, Augustin, M. 登録日 2014-07-08 公開日 2014-09-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
4TV3	Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design 分子名称: 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Chen, P, Deng, Y.-L, Bergqvist, S, Falk, M, Liu, W, Timofeevski, S. 登録日 2014-06-25 公開日 2014-08-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design. Protein Sci., 23, 2014

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