4TYT
Crystal Structure of BcII metallo-beta-lactamase in complex with ML302F
Summary for 4TYT
Entry DOI | 10.2210/pdb4tyt/pdb |
Descriptor | Beta-lactamase 2, ZINC ION, (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, ... (6 entities in total) |
Functional Keywords | antimicrobial resistance, metallo beta lactamase, inhibitor, hydrolase |
Biological source | Bacillus cereus |
Cellular location | Periplasm : P04190 |
Total number of polymer chains | 1 |
Total formula weight | 25598.07 |
Authors | Brem, J.,van Berkel, S.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-07-09, release date: 2014-11-26, Last modification date: 2023-12-20) |
Primary citation | Brem, J.,van Berkel, S.S.,Aik, W.,Rydzik, A.M.,Avison, M.B.,Pettinati, I.,Umland, K.D.,Kawamura, A.,Spencer, J.,Claridge, T.D.,McDonough, M.A.,Schofield, C.J. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. Nat.Chem., 6:1084-1090, 2014 Cited by PubMed: 25411887DOI: 10.1038/nchem.2110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.799 Å) |
Structure validation
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