2M5Q
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2MD2
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2ME8
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2M58
| Structure of 2'-5' AG1 lariat forming ribozyme in its inactive state | 分子名称: | RNA (59-MER) | 著者 | Carlomagno, T, Amata, I, Codutti, L, Falb, M, Fohrer, J, Simon, B. | 登録日 | 2013-02-18 | 公開日 | 2013-04-03 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural principles of RNA catalysis in a 2'-5' lariat-forming ribozyme. J.Am.Chem.Soc., 135, 2013
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2M92
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2M1H
| Solution structure of a PWWP domain from Trypanosoma brucei | 分子名称: | Transcription elongation factor S-II | 著者 | Wang, R, Fan, K, Liao, S, Zhang, J, Tu, X. | 登録日 | 2012-11-28 | 公開日 | 2013-12-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei. Proteins, 84, 2016
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2LV3
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2M91
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2M90
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2MJR
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2M8I
| Structure of Pin1 WW domain | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Luh, L.M, Kirchner, D.K, Loehr, F, Haensel, R, Doetsch, V. | 登録日 | 2013-05-22 | 公開日 | 2014-04-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition. J.Am.Chem.Soc., 135, 2013
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2M8Y
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6BFX
| BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-{(1S,2S)-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-1-hydroxypropan-2-yl}acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-27 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFE
| BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-[(1R,2S)-1-[(2R,4R)-4-(cyclohexylmethoxy)pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-26 | 公開日 | 2017-11-15 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFD
| BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | 2-{[(2S)-butan-2-yl]amino}-N-{(1R,2S)-1-hydroxy-3-phenyl-1-[(2R)-pyrrolidin-2-yl]propan-2-yl}-6-(methylsulfonyl)pyridine-4-carboxamide, Beta-secretase 1, GLYCEROL | 著者 | Timm, D.E. | 登録日 | 2017-10-26 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFW
| BACE crystal structure with hydroxy morpholine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-27 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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2BIO
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2BIP
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2BIN
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2BIM
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2BIQ
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4WRQ
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4KEJ
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4KEI
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4KEK
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