PDB: 186017 件ウェブページステータス検索Chemie searchBIRD

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8TNP	Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 分子名称: DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
6LMQ	Crystal structure of HIV-1 integrase catalytic core domain in complex with 2-(tert-butoxy)-2-[3-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-6-methanesulfonamido-2,3',4',5-tetramethyl-[1,1'-biphenyl]-4-yl]acetic acid 分子名称: (2S)-2-[2-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-4-(3,4-dimethylphenyl)-3,6-dimethyl-5-(methylsulfonylamino)phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase catalytic, SULFATE ION, ... 著者 Sugiyama, S, Iwaki, T, Tamura, Y, Tomita, K, Matsuoka, E, Arita, S, Seki, T, Yoshinaga, T, Kawasuji, T. 登録日 2019-12-26 公開日 2020-09-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold. Bioorg.Med.Chem., 28, 2020
8EAK	SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 2 分子名称: 46-mer DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
6S8R	D. melanogaster RNA helicase Me31B in complex with GIGYF 分子名称: ACETATE ION, ATP-dependent RNA helicase me31b, GIGYF family protein CG11148 著者 Peter, D, Valkov, E. 登録日 2019-07-10 公開日 2019-09-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression. Genes Dev., 33, 2019
8EAM	SsoMCM hexamer bound to Mg/ADP-BeFx and DNA. Class 2. Merged particles from datasets with 3 different DNA entities 分子名称: DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
8EAJ	SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 1 分子名称: 46-mer DNA strand, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.45 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
6I9I	Rift valley fever virus Gn in complex with a neutralizing antibody fragment 分子名称: Glycoprotein, RV-Gn1 Heavy chain, RV-Gn1 Light chain 著者 Allen, E.R, Bowden, T.A. 登録日 2018-11-23 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus. Cell Rep, 25, 2018
5JR4	Crystal structure of FimH A27V/V163A from E. coli UTI89 bound to FimG N-terminal extension 分子名称: CALCIUM ION, FimG N-terminal extension, GLYCEROL, ... 著者 Kalas, V, Hultgren, S.J. 登録日 2016-05-05 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.596 Å) 主引用文献 Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions. Sci Adv, 3, 2017
8TQM	Cryo-EM structure of E3 ubiquitin ligase Doa10 from Saccharomyces cerevisiae 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ERAD-associated E3 ubiquitin-protein ligase DOA10, ... 著者 Park, E, Itskanov, S.I. 登録日 2023-08-07 公開日 2024-03-13 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10. Nat Commun, 15, 2024
7U8Y	TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics 分子名称: ALIZARIN RED, MANGANESE (II) ION, Three-prime repair exonuclease 1 著者 Hemphill, W.O, Harvey, S.E, Simpson, S.R, Smalley, T.L, Salsbury, F.R, Perrino, F.W, Hollis, T. 登録日 2022-03-09 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics to be published
6BWD	3.7 angstrom cryoEM structure of truncated mouse TRPM7 分子名称: CHOLESTEROL HEMISUCCINATE, MAGNESIUM ION, Transient receptor potential cation channel subfamily M member 7 著者 Zhang, J, Li, Z, Duan, J, Li, J, Hulse, R.E, Santa-Cruz, A, Abiria, S.A, Krapivinsky, G, Clapham, D.E. 登録日 2017-12-14 公開日 2018-08-15 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8EAF	SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 1 分子名称: 12-mer oligo dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.62 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
5JSP	New Mechanistic Insight from Substrate and Product Bound Structures of the Metal-dependent Dimethylsulfoniopropionate Lyase DddQ 分子名称: 3-(dimethyl-lambda~4~-sulfanyl)propanoic acid, BROMIDE ION, CHLORIDE ION, ... 著者 Brummett, A.E, Dey, M. 登録日 2016-05-09 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 New Mechanistic Insight from Substrate- and Product-Bound Structures of the Metal-Dependent Dimethylsulfoniopropionate Lyase DddQ. Biochemistry, 55, 2016
7THA	Crystal structure of human transthyretin variant C10A/M13V 分子名称: CALCIUM ION, Transthyretin 著者 Jaeger, M, Mortenson, D.E, Yan, N.L, Kelly, J.W. 登録日 2022-01-10 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Lysine carbamylation competes with urea unfolding of human transthyretin introducing kinetic heterogeneity To Be Published
7TXR	Crystal structure of the Vitronectin hemopexin-like domain binding Calcium-2 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 Aleshin, A.E, Marassi, F.M. 登録日 2022-02-09 公開日 2023-03-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for calcium-induced thermostability of human vitronectin To Be Published
8EAH	SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 1 分子名称: 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.48 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
8E5W	Crystal structure of dehydroalanine Hip1 分子名称: DI(HYDROXYETHYL)ETHER, PALMITIC ACID, Protease, ... 著者 Goldfarb, N.E, Brooks, C.L, Ostrov, D.A. 登録日 2022-08-22 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 2.1 angstrom crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1). Biochem.Biophys.Res.Commun., 630, 2022
7U68	Crystal structure of the Vitronectin hemopexin-like domain binding Sodium-2 分子名称: CHLORIDE ION, SODIUM ION, SULFATE ION, ... 著者 Aleshin, A.E, Marassi, F.M. 登録日 2022-03-03 公開日 2023-03-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for calcium-induced thermostability of human vitronectin To Be Published
6BVE	Triosephosphate isomerase of Synechocystis in complex with 2-Phosphoglycolic acid 分子名称: 2-PHOSPHOGLYCOLIC ACID, SODIUM ION, Triosephosphate isomerase 著者 Jimenez-Sandoval, P, Castro-Torres, E, Brieba, L.G. 登録日 2017-12-12 公開日 2018-12-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Basis for the Limited Response to Oxidative and Thiol-Conjugating Agents by Triosephosphate Isomerase From the Photosynthetic BacteriaSynechocystis. Front Mol Biosci, 5, 2018
5JUW	complex of Dot1l with SS148 分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... 著者 Yu, W, Tempel, W, Li, Y, Spurr, S.S, Bayle, E.D, Fish, P.V, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2016-05-10 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Complex of Dot1l with SS148 To Be Published
8EBO	Homopurine parallel G-quadruplex from human chromosome 7 stabilized by K+ ions 分子名称: COBALT (III) ION, DNA (5'-D(*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*AP*AP*AP*GP*GP*GP*GP*A)-3'), N-METHYLMESOPORPHYRIN, ... 著者 Chen, E.V, Yatsunyk, L.A. 登録日 2022-08-31 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Homopurine guanine-rich sequences in complex with N-methyl mesoporphyrin IX form parallel G-quadruplex dimers and display a unique symmetry tetrad. Bioorg.Med.Chem., 77, 2022
6BZH	Structure of mouse RIG-I tandem CARDs 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58 著者 Kershaw, N.J, D'Cruz, A.A, Babon, J.J, Nicholson, S.E. 登録日 2017-12-24 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of a second binding site on the TRIM25 B30.2 domain. Biochem. J., 475, 2018
8EAG	SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 2 分子名称: 12-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... 著者 Meagher, M, Myasnikov, A, Enemark, E.J. 登録日 2022-08-29 公開日 2022-12-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
6SD2	Structure of the RBM2inner region of the Salmonella flagella MS-ring protein FliF with 21-fold symmetry applied. 分子名称: Flagellar M-ring protein 著者 Johnson, S, Fong, Y.H, Deme, J.C, Furlong, E.J, Kuhlen, L, Lea, S.M. 登録日 2019-07-26 公開日 2020-03-18 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nat Microbiol, 5, 2020
6I3Z	Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen 分子名称: Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... 著者 Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A. 登録日 2018-11-08 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020

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