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5JH5
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Structural Basis for the Hierarchical Assembly of the Core of PRC1.1
分子名称: BCL-6 corepressor-like protein 1, Lysine-specific demethylase 2B, Polycomb group RING finger protein 1, ...
著者Wong, S.J, Taylor, A.B, Hart, P.J, Kim, C.A.
登録日2016-04-20
公開日2016-09-14
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.
Structure, 24, 2016
7BH9
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BU of 7bh9 by Molmil
SARS-CoV-2 RBD-62 in complex with ACE2 peptidase domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
著者Elad, N, Dym, O, Zahradnik, J, Schreiber, G.
登録日2021-01-11
公開日2021-02-17
最終更新日2021-09-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.
Nat Microbiol, 6, 2021
6VI4
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BU of 6vi4 by Molmil
Nanobody-Enabled Monitoring of Kappa Opioid Receptor States
分子名称: (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CHOLESTEROL, Kappa opioid receptor, ...
著者Che, T, Roth, B.L.
登録日2020-01-11
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nanobody-enabled monitoring of kappa opioid receptor states.
Nat Commun, 11, 2020
6NDL
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BU of 6ndl by Molmil
Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor
分子名称: 1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea, Biotin Protein Ligase, GLYCEROL
著者Marshall, A.C, Polyak, S.W, Bruning, J.B, Lee, K.
登録日2018-12-13
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.
Acs Chem.Biol., 14, 2019
8QYM
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BU of 8qym by Molmil
Human 20S proteasome assembly intermediate structure 3
分子名称: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
著者Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
登録日2023-10-26
公開日2024-02-21
最終更新日2024-04-17
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 2024
8QZ9
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BU of 8qz9 by Molmil
Human 20S proteasome assembly intermediate structure 4
分子名称: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
著者Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
登録日2023-10-26
公開日2024-02-21
最終更新日2024-04-17
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 2024
8QYN
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Human 20S proteasome assembly intermediate structure 5
分子名称: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
著者Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
登録日2023-10-26
公開日2024-02-21
最終更新日2024-04-17
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 2024
8QYL
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Human 20S proteasome assembly intermediate structure 2
分子名称: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
著者Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
登録日2023-10-26
公開日2024-02-21
最終更新日2024-04-17
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 2024
6NLY
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BU of 6nly by Molmil
Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain
分子名称: Alanine--tRNA ligase, mitochondrial
著者Kuhle, B, Schimmel, P.
登録日2019-01-09
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.307 Å)
主引用文献Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
7OT8
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DeNovoTIM6-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 2)
分子名称: DeNovoTIM6-SB, SULFATE ION
著者Kordes, S, Romero-Romero, S, Hocker, B.
登録日2021-06-09
公開日2021-12-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels.
Protein Sci., 31, 2022
8QHD
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Hantaan virus polymerase in hexameric state
分子名称: RNA-directed RNA polymerase L
著者Durieux Trouilleton, Q, Arragain, B, Malet, H.
登録日2023-09-07
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers.
Nat Commun, 15, 2024
5I9V
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BU of 5i9v by Molmil
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with AGS
分子名称: Ephrin type-A receptor 2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Kudlinzki, D, Linhard, V.L, Gande, S.L, Sreeramulu, S, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.458 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA3
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BU of 5ia3 by Molmil
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with PD173955
分子名称: 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, Ephrin type-A receptor 2
著者Kudlinzki, D, Linhard, V.L, Gande, S.L, Sreeramulu, S, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.788 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
7A92
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BU of 7a92 by Molmil
Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Unmasked Refinement)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Benton, D.J, Wrobel, A.G, Rosenthal, P.B, Gamblin, S.J.
登録日2020-09-01
公開日2020-09-30
最終更新日2020-12-16
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion.
Nature, 588, 2020
8PKX
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BU of 8pkx by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 11 (ortho-WRCNPETaEC).
分子名称: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Braun, M.B, Bischof, L, Hartmann, M.D.
登録日2023-06-27
公開日2023-11-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
6HU1
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BU of 6hu1 by Molmil
Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10
分子名称: 4-chloranyl-3-[(2,4-dichlorophenyl)carbonylamino]-~{N}-oxidanyl-benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ...
著者Shaik, T.B, Marek, M, Romier, C.
登録日2018-10-05
公開日2018-10-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.996 Å)
主引用文献Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
8PKV
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BU of 8pkv by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDEETGEC).
分子名称: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Braun, M.B, Bischof, L, Hartmann, M.D.
登録日2023-06-27
公開日2023-11-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
6Z0O
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BU of 6z0o by Molmil
Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein
分子名称: Affimer-NP, Nucleocapsid
著者Alvarez-Rodriguez, B, Tiede, C, Trinh, C, Tomlinson, D, Edwards, T.A, Barr, J.N.
登録日2020-05-10
公開日2020-05-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5974 Å)
主引用文献Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Plos Negl Trop Dis, 14, 2020
1C0Q
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BU of 1c0q by Molmil
COMPLEX OF VANCOMYCIN WITH 2-ACETOXY-D-PROPANOIC ACID
分子名称: CHLORIDE ION, LACTIC ACID, VANCOMYCIN, ...
著者Loll, P.J, Kaplan, J, Selinsky, B, Axelsen, P.H.
登録日1999-07-20
公開日1999-07-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Vancomycin binding to low-affinity ligands: delineating a minimum set of interactions necessary for high-affinity binding.
J.Med.Chem., 42, 1999
7OD1
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BU of 7od1 by Molmil
Crystal structure of RBR ubiquitin ligase ARIH2
分子名称: E3 ubiquitin-protein ligase ARIH2, ZINC ION
著者Kostrhon, S.P, Prabu, J.R, Schulman, B.A.
登録日2021-04-28
公開日2021-09-15
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
Nat.Chem.Biol., 17, 2021
1BKV
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BU of 1bkv by Molmil
COLLAGEN
分子名称: ACETIC ACID, T3-785
著者Kramer, R.Z, Bella, J, Mayville, P, Brodsky, B, Berman, H.M.
登録日1998-07-13
公開日1999-02-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Sequence dependent conformational variations of collagen triple-helical structure.
Nat.Struct.Biol., 6, 1999
8PM6
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BU of 8pm6 by Molmil
Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL
著者Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
登録日2023-06-28
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
6BPY
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BU of 6bpy by Molmil
Aspergillus fumigatus Thioredoxin Reductase
分子名称: ACETATE ION, D-MALATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Marshall, A.C, Bruning, J.B.
登録日2017-11-27
公開日2019-01-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献Structure, Mechanism, and Inhibition ofAspergillus fumigatusThioredoxin Reductase.
Antimicrob.Agents Chemother., 63, 2019
6VYM
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Cryo-EM structure of mechanosensitive channel MscS in PC-18:1 nanodiscs treated with beta-cyclodextran
分子名称: Mechanosensitive channel MscS
著者Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T.
登録日2020-02-27
公開日2021-02-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Visualization of the mechanosensitive ion channel MscS under membrane tension.
Nature, 590, 2021
6VYL
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Cryo-EM structure of mechanosensitive channel MscS in PC-10 nanodiscs
分子名称: Mechanosensitive channel MscS
著者Zhang, Y, Daday, C, Gu, R, Cox, C.D, Martinac, B, Groot, B, Walz, T.
登録日2020-02-27
公開日2021-02-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Visualization of the mechanosensitive ion channel MscS under membrane tension.
Nature, 590, 2021

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