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6HU1

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10

Summary for 6HU1
Entry DOI10.2210/pdb6hu1/pdb
DescriptorHistone deacetylase, ZINC ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywordsepigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase
Biological sourceSchistosoma mansoni
Total number of polymer chains4
Total formula weight207109.28
Authors
Shaik, T.B.,Marek, M.,Romier, C. (deposition date: 2018-10-05, release date: 2018-10-31, Last modification date: 2024-01-24)
Primary citationMarek, M.,Shaik, T.B.,Heimburg, T.,Chakrabarti, A.,Lancelot, J.,Ramos-Morales, E.,Da Veiga, C.,Kalinin, D.,Melesina, J.,Robaa, D.,Schmidtkunz, K.,Suzuki, T.,Holl, R.,Ennifar, E.,Pierce, R.J.,Jung, M.,Sippl, W.,Romier, C.
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61:10000-10016, 2018
Cited by
PubMed: 30347148
DOI: 10.1021/acs.jmedchem.8b01087
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.996 Å)
Structure validation

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