PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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6PR7	S. aureus dihydrofolate reductase co-crystallized with benzyl-dihydropthalazine inhibitor and NADP(H) 分子名称: (2E)-1-[(1S)-1-benzylphthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one, Dihydrofolate reductase, GLYCEROL, ... 著者 Bourne, C.R, Thomas, L.M. 登録日 2019-07-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200, 2020
6PR9	S. aureus dihydrofolate reductase co-crystallized with 1-ethylpropyl-dihydropthalazine inhibitor and NADP(H) 分子名称: (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(pentan-3-yl)-3,4-dihydrophthalazin-2(1H)-yl]prop-2-en-1-one, Dihydrofolate reductase, GLYCEROL, ... 著者 Bourne, C.R, Thomas, L.M. 登録日 2019-07-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200, 2020
4CL6	Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine 分子名称: 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-(4-chlorobenzyl)-5-(furan-2-yl)-1H-1,2,4-triazol-3-amine 著者 Moynie, L, McMahon, S.A, Duthie, F.G, Naismith, J.H. 登録日 2014-01-13 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 A Substrate Mimic Allows High Throughput Assay of the Faba Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas Aeruginosa Faba. J.Mol.Biol., 428, 2016
6PR8	S. aureus dihydrofoate reductase co-crystallized with 3,5-dimethylphenyl-dihydropthalazine inhibitor and NADP(H) 分子名称: (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(3,5-dimethylphenyl)phthalazin-2(1H)-yl]prop-2-en-1-one, Dihydrofolate reductase, GLYCEROL, ... 著者 Bourne, C.R, Thomas, L.M. 登録日 2019-07-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200, 2020
6PRA	S. aureus dihydrofolate reductase with NADP(H) and empty folate pocket 分子名称: Dihydrofolate reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Bourne, C.R, Thomas, L.M. 登録日 2019-07-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200, 2020
3D6R	Structure of an avian influenza A virus NS1 protein effector domain 分子名称: Non-structural protein 1 著者 Hale, B.G, Barclay, W.S, Randall, R.E, Russell, R.J. 登録日 2008-05-20 公開日 2008-08-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Structure of an avian influenza A virus NS1 protein effector domain. Virology, 378, 2008
3ZYC	DYNAMIN 1 GTPASE GED FUSION DIMER COMPLEXED WITH GMPPCP 分子名称: DYNAMIN-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Chappie, J.S, Mears, J.A, Fang, S, Leonard, M, Schmid, S.L, Milligan, R.A, Hinshaw, J.E, Dyda, F. 登録日 2011-08-22 公開日 2011-10-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke. Cell(Cambridge,Mass.), 147, 2011
6VUM	Structure of nevanimibe-bound human tetrameric ACAT1 分子名称: CHOLESTEROL, COENZYME A, OLEIC ACID, ... 著者 Li, X, Long, T. 登録日 2020-02-16 公開日 2020-05-13 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Structure of nevanimibe-bound tetrameric human ACAT1. Nature, 581, 2020
2WGF	Crystal structure of Mycobacterium tuberculosis C171Q KasA variant 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
3JZO	Human MDMX liganded with a 12mer peptide (pDI) 分子名称: POTASSIUM ION, Protein Mdm4, pDI peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-23 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
6VWJ	Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II 分子名称: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain 著者 Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. 登録日 2020-02-19 公開日 2020-05-13 最終更新日 2020-07-22 実験手法 ELECTRON MICROSCOPY (4.21 Å) 主引用文献 How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6T16	ASR Alternansucrase in complex with panose 分子名称: Alternansucrase, CALCIUM ION, alpha-D-glucopyranose, ... 著者 Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M. 登録日 2019-10-03 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation. J.Biol.Chem., 295, 2020
3K7I	Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain 分子名称: Indian hedgehog protein, SULFATE ION, ZINC ION 著者 He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. 登録日 2009-10-13 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.438 Å) 主引用文献 Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain To be Published
6SZI	ASR Alternansucrase in complex with isomaltose 分子名称: Alternansucrase, CALCIUM ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose 著者 Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M. 登録日 2019-10-02 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation. J.Biol.Chem., 295, 2020
6W2T	Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2) 分子名称: 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... 著者 Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. 登録日 2020-03-08 公開日 2020-04-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate. Elife, 9, 2020
6SLT	Flavin-dependent tryptophan 6-halogenase Thal in complex with tryptophan and FAD 分子名称: ADENOSINE MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Moritzer, A, Niemann, H.H. 登録日 2019-08-20 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled. Protein Sci., 28, 2019
4IQP	Crystal Structure of HCRA-W1266A 分子名称: Botulinum neurotoxin type A, GLYCEROL 著者 Fu, Z, Kroken, A.R, Barbieri, J.T, Kim, J.-J.P. 登録日 2013-01-12 公開日 2013-05-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Enhancing the Protective Immune Response against Botulism. Infect.Immun., 81, 2013
6SMT	S-enantioselective imine reductase from Mycobacterium smegmatis 分子名称: (2S)-2-ethylhexan-1-ol, 1,2-ETHANEDIOL, 6-phosphogluconate dehydrogenase, ... 著者 Meyer, T, Zumbraegel, N, Geerds, C, Groeger, H, Niemann, H.H. 登録日 2019-08-22 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Characterization of an S -enantioselective Imine Reductase from Mycobacterium Smegmatis . Biomolecules, 10, 2020
6SUL	Amicoumacin kinase AmiN in complex with AMP-PNP, Mg2+ and Ami 分子名称: Amicoumacin A, CHLORIDE ION, MAGNESIUM ION, ... 著者 Bourenkov, G.P, Mokrushina, Y.A, Terekhov, S.S, Smirnov, I.V, Gabibov, A.G, Altman, S. 登録日 2019-09-15 公開日 2020-07-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding. Sci Adv, 6, 2020
6WBQ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Tubastatin A 分子名称: 1,2-ETHANEDIOL, 4-[(2-methyl-3,4-dihydro-1~{H}-pyrido[4,3-b]indol-5-yl)methyl]-~{N}-oxidanyl-benzamide, PHOSPHATE ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2020-03-27 公開日 2020-07-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chem.Biol., 15, 2020
6SS7	Human Leukocyte Antigen Class I A02 Carrying LLWAGPMAV 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... 著者 Rizkallah, P.J, Bovay, A. 登録日 2019-09-06 公開日 2020-07-15 最終更新日 2020-07-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222by combinatorial peptide library screening. Mol.Immunol., 125, 2020
6PSD	Complex of CRACR2a with a Dynein Light Intermediate Chain Peptide 分子名称: CALCIUM ION, EF-hand calcium-binding domain-containing protein 4B, cDNA FLJ10219 fis, ... 著者 Dominguez, R, Lee, I.G. 登録日 2019-07-12 公開日 2020-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner. Nat Commun, 11, 2020
4JXJ	Crystal Structure of Ribosomal RNA small subunit methyltransferase A from Rickettsia bellii Determined by Iodide SAD Phasing 分子名称: 1,2-ETHANEDIOL, IODIDE ION, Ribosomal RNA small subunit methyltransferase A 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-03-28 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Ribosomal RNA small subunit methyltransferase A from Rickettsia bellii Determined by Iodide SAD Phasing TO BE PUBLISHED
6ST7	Crystal Structure of Domain Swapped Trp Repressor V58I Variant with bound L-trp 分子名称: ISOPROPYL ALCOHOL, TRYPTOPHAN, Trp operon repressor 著者 Sprenger, J, Lawson, C.L, Carey, J, Drouard, F, von Wachenfeldt, C, Schulz, A, Linse, S, Lo Leggio, L. 登録日 2019-09-10 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan. Acta Crystallogr.,Sect.F, 77, 2021
6VRM	T cell receptor-p53-HLA-A2 complex 分子名称: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen, ... 著者 Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A. 登録日 2020-02-08 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun, 11, 2020

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