6PRA
S. aureus dihydrofolate reductase with NADP(H) and empty folate pocket
Summary for 6PRA
| Entry DOI | 10.2210/pdb6pra/pdb |
| Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Staphylococcus aureus |
| Total number of polymer chains | 1 |
| Total formula weight | 19670.13 |
| Authors | Bourne, C.R.,Thomas, L.M. (deposition date: 2019-07-10, release date: 2020-06-17, Last modification date: 2023-10-11) |
| Primary citation | Muddala, N.P.,White, J.C.,Nammalwar, B.,Pratt, I.,Thomas, L.M.,Bunce, R.A.,Berlin, K.D.,Bourne, C.R. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200:112412-112412, 2020 Cited by PubMed: 32502861DOI: 10.1016/j.ejmech.2020.112412 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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