PDB: 41522 件ウェブページステータス検索Chemie searchBIRD

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5IFW	Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death 分子名称: ADENOSINE-5'-DIPHOSPHATE, Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase 著者 Roske, Y, Heinemann, U. 登録日 2016-02-26 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun, 7, 2016
6M91	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex 分子名称: 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid, CHLORIDE ION, Catenin beta-1, ... 著者 Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. 登録日 2018-08-22 公開日 2019-04-03 最終更新日 2019-04-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
6M9C	PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Pseudotyrostatin 分子名称: ACETIC ACID, CALCIUM ION, Pseudotyrostatin, ... 著者 Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. 登録日 2018-08-23 公開日 2018-10-24 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase Biochemistry, 40, 2001
7DH9	The co-crystal structure of DYRK2 with a small molecule inhibitor 7 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol 著者 Wei, T, Xiao, J. 登録日 2020-11-13 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.194 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
4H11	Interaction partners of PSD-93 studied by X-ray crystallography and fluorescent polarization spectroscopy 分子名称: ACETATE ION, Disks large homolog 2, SULFATE ION 著者 Fiorentini, M, Kastrup, J.S, Gajhede, M. 登録日 2012-09-10 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. Acta Crystallogr.,Sect.D, 69, 2013
2H5K	Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2 分子名称: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand 著者 Benfield, A.P, Whiddon, B.B, Martin, S.F. 登録日 2006-05-26 公開日 2006-08-15 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
7DHC	The co-crystal structure of DYRK2 with a small molecule inhibitor 10 分子名称: 4-[bis(fluoranyl)methyl]-2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 著者 Wei, T, Xiao, J. 登録日 2020-11-13 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.592 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DHH	The co-crystal structure of DYRK2 with a small molecule inhibitor 19 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [9-(azetidin-3-ylmethylsulfanyl)-2,7-dimethoxy-acridin-4-yl]methanol 著者 Wei, T, Xiao, J. 登録日 2020-11-14 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.486 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
4H40	Crystal structure of a putative cell adhesion protein (BF2867) from Bacteroides fragilis NCTC 9343 at 2.57 A resolution 分子名称: CHLORIDE ION, putative cell adhesion protein 著者 Joint Center for Structural Genomics (JCSG) 登録日 2012-09-14 公開日 2012-10-03 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 A Distinct Type of Pilus from the Human Microbiome. Cell, 165, 2016
7DHO	The co-crystal structure of DYRK2 with a small molecule inhibitor 14 分子名称: 2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 著者 Wei, T, Xiao, J. 登録日 2020-11-16 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DHN	The co-crystal structure of DYRK2 with a small molecule inhibitor 20 分子名称: 7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline, Dual specificity tyrosine-phosphorylation-regulated kinase 2 著者 Wei, T, Xiao, J. 登録日 2020-11-16 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DHK	The co-crystal structure of DYRK2 with a small molecule inhibitor 13 分子名称: 2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 著者 Wei, T, Xiao, J. 登録日 2020-11-16 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.341 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
7DHV	The co-crystal structure of DYRK2 with a small molecule inhibitor 8 分子名称: 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine-4-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 2 著者 Wei, T, Xiao, J. 登録日 2020-11-17 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.679 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
2GSK	Structure of the BtuB:TonB Complex 分子名称: CALCIUM ION, CYANOCOBALAMIN, HEXANE, ... 著者 Shultis, D.D, Purdy, M.P, Banchs, C.N, Wiener, M.C. 登録日 2006-04-26 公開日 2006-06-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Outer membrane active transport: structure of the BtuB:TonB complex Science, 312, 2006
4H5O	Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Pentamer Bound to Single-stranded RNA 分子名称: 35-mer poly(U) RNA, Nucleocapsid protein 著者 Raymond, D.D, Smith, J.L. 登録日 2012-09-18 公開日 2012-11-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
7ZMD	Ketosynthase domain of module 3 from Brevibacillus Brevis orphan BGC11 分子名称: Putative polyketide synthase 著者 Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. 登録日 2022-04-19 公開日 2022-09-21 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
5II2	Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, CITRIC ACID, POTASSIUM ION, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S. 登録日 2016-03-01 公開日 2016-06-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. J.Med.Chem., 59, 2016
8RGP	Closed Complex I from murine brain 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... 著者 Vercellino, I, Sazanov, L.A. 登録日 2023-12-14 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 SCAF1 drives the compositional diversity of mammalian respirasomes. Nat.Struct.Mol.Biol., 2024
7ZMC	Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11 分子名称: Putative polyketide synthase 著者 Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. 登録日 2022-04-19 公開日 2022-09-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
7ZMA	Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11 分子名称: Putative polyketide synthase 著者 Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. 登録日 2022-04-19 公開日 2022-09-21 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
6LVB	Structure of Dimethylformamidase, tetramer 分子名称: FE (III) ION, N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit 著者 Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. 登録日 2020-02-02 公開日 2020-06-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase. Angew.Chem.Int.Ed.Engl., 59, 2020
8A9L	Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies 分子名称: Alpha-synuclein, Unknown fragment 著者 Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. 登録日 2022-06-28 公開日 2022-08-31 最終更新日 2022-11-09 実験手法 ELECTRON MICROSCOPY (2.16 Å) 主引用文献 Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610, 2022
4LCK	Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA 分子名称: MAGNESIUM ION, Ribosomal protein YbxF, STRONTIUM ION, ... 著者 Zhang, J, Ferre-D'Amare, A.R. 登録日 2013-06-21 公開日 2013-07-31 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature, 500, 2013
5IJR	X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand. 分子名称: DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1 著者 Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. 登録日 2016-03-02 公開日 2017-03-29 最終更新日 2018-07-11 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
7DJO	The co-crystal structure of DYRK2 with a small molecule inhibitor 17 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol 著者 Wei, T, Xiao, J. 登録日 2020-11-20 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022

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