7DHN
The co-crystal structure of DYRK2 with a small molecule inhibitor 20
Summary for 7DHN
Entry DOI | 10.2210/pdb7dhn/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 2, 7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline (3 entities in total) |
Functional Keywords | kinase, inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38067.21 |
Authors | |
Primary citation | Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11:-, 2022 Cited by PubMed: 35439114DOI: 10.7554/eLife.77696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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