7DHO
The co-crystal structure of DYRK2 with a small molecule inhibitor 14
Summary for 7DHO
Entry DOI | 10.2210/pdb7dho/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 2, 2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine (2 entities in total) |
Functional Keywords | kinase, inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38072.18 |
Authors | |
Primary citation | Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11:-, 2022 Cited by PubMed: 35439114DOI: 10.7554/eLife.77696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.29 Å) |
Structure validation
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