7DH9

The co-crystal structure of DYRK2 with a small molecule inhibitor 7

Summary for 7DH9

Entry DOI	10.2210/pdb7dh9/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol (3 entities in total)
Functional Keywords	kinase, inhibitor, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38074.15
Authors	Wei, T.,Xiao, J. (deposition date: 2020-11-13, release date: 2021-11-17, Last modification date: 2023-11-29)
Primary citation	Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11:-, 2022 Cited by PubMed: 35439114 DOI: 10.7554/eLife.77696 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.194 Å)

Structure validation