4JTZ
| Crystal structure of hcv ns5b polymerase in complex with compound 4 | 分子名称: | 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-N-(pyridin-3-yl)-2-(trifluoromethyl)benzamide, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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4J0A
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3GTG
| Backtracked RNA polymerase II complex with 12mer RNA | 分子名称: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | 登録日 | 2009-03-27 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.78 Å) | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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4JTY
| Crystal structure of HCV NS5B polymerase with COMPOUND 2 | 分子名称: | 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-2-(trifluoromethyl)benzamide, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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4JTW
| Crystal structure of HCV NS5B polymerase in complex with coupound 1 | 分子名称: | 1-(2,4,6-trifluorobenzyl)-6-[2-(trifluoromethyl)phenoxy]quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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3GTJ
| Backtracked RNA polymerase II complex with 13mer RNA | 分子名称: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | 登録日 | 2009-03-27 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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4JU2
| Crystal structure of hcv ns5b polymerase in complex with compound 12 | 分子名称: | 6-[3-(pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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8B3F
| Pol II-CSB-CSA-DDB1-ELOF1 | 分子名称: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | 著者 | Kokic, G, Cramer, P. | 登録日 | 2022-09-16 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Pol II-CSB-CSA-DDB1-ELOF1 structure. To Be Published
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8B3D
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3GTL
| Backtracked RNA polymerase II complex with 13mer with G<>U mismatch | 分子名称: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | 登録日 | 2009-03-27 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTO
| Backtracked RNA polymerase II complex with 15mer RNA | 分子名称: | DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | 登録日 | 2009-03-27 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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3GTQ
| Backtracked RNA polymerase II complex induced by damage | 分子名称: | DNA (5'-D(*CP*TP*AP*CP*CP*CP*AP*TP*AP*AP*CP*CP*AP*CP*AP*GP*GP*CP*TP*CP*CP*TP*CP*TP*CP*CP*AP*TP*C)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D. | 登録日 | 2009-03-27 | 公開日 | 2009-06-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science, 324, 2009
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1A1D
| YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY | 分子名称: | RNA POLYMERASE | 著者 | Krapp, S, Kelly, G, Reischl, J, Weinzierl, R, Matthews, S. | 登録日 | 1997-12-10 | 公開日 | 1999-03-02 | 最終更新日 | 2024-04-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family. Nat.Struct.Biol., 5, 1998
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3KOA
| M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA and GTP | 分子名称: | 3D polymerase, DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | 登録日 | 2009-11-13 | 公開日 | 2010-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KNA
| M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA | 分子名称: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | 著者 | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | 登録日 | 2009-11-12 | 公開日 | 2010-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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7ORN
| La Crosse virus polymerase at replication initiation stage | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, La Crosse virus polymerase, MAGNESIUM ION, ... | 著者 | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | 登録日 | 2021-06-06 | 公開日 | 2022-02-16 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
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8S54
| RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabber, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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8S55
| RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
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3CQZ
| Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin | 分子名称: | ALPHA-AMANITIN, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... | 著者 | Kaplan, C.D, Larsson, K.-M, Kornberg, R.D. | 登録日 | 2008-04-03 | 公開日 | 2008-07-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin. Mol.Cell, 30, 2008
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3KMS
| G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure | 分子名称: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | 著者 | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | 登録日 | 2009-11-11 | 公開日 | 2010-07-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3KMQ
| G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal structure | 分子名称: | 3D polymerase, RNA (5'-R(*GP*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*CP*C)-3') | 著者 | Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. | 登録日 | 2009-11-11 | 公開日 | 2010-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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2HAI
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3HVO
| Structure of the genotype 2B HCV polymerase bound to a NNI | 分子名称: | 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, Genome polyprotein | 著者 | Rydberg, E.H, Carfi, A. | 登録日 | 2009-06-16 | 公開日 | 2009-08-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors To be Published
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1PQV
| RNA polymerase II-TFIIS complex | 分子名称: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 14.2 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, ... | 著者 | Kettenberger, H, Armache, K.-J, Cramer, P. | 登録日 | 2003-06-19 | 公開日 | 2003-08-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage Cell(Cambridge,Mass.), 114, 2003
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8WB0
| De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS | 分子名称: | Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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