PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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3UDH	Crystal Structure of BACE with Compound 1 分子名称: (3S)-spiro[indole-3,3'-pyrrolidin]-2(1H)-one, 1,2-ETHANEDIOL, Beta-secretase 1, ... 著者 Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. 登録日 2011-10-28 公開日 2012-04-18 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
3UDM	Crystal Structure of BACE with Compound 8 分子名称: 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... 著者 Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. 登録日 2011-10-28 公開日 2012-04-18 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
3G00	Mth0212 in complex with a 9bp blunt end dsDNA at 1.7 Angstrom 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-D(*CP*GP*TP*AP*TP*TP*AP*CP*G)-3', 5'-D(*CP*GP*TP*AP*UP*TP*AP*CP*G)-3', ... 著者 Lakomek, K, Dickmanns, A, Ficner, R. 登録日 2009-01-27 公開日 2010-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA J.Mol.Biol., 399, 2010
3UDQ	Crystal Structure of BACE with Compound 13 分子名称: (4S)-6-bromo-1,1-dioxido-3,4-dihydro-2H-thiochromen-4-yl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate, Beta-secretase 1 著者 Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. 登録日 2011-10-28 公開日 2012-04-18 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
3UE2	Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.23 A resolution 分子名称: Poly(U)-binding-splicing factor PUF60, SULFATE ION 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2011-10-28 公開日 2011-11-30 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.23 A resolution To be published
3PHB	Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG 分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase 著者 Ho, M, Cassera, M.B, Murkin, A.S, Almo, S.C, Schramm, V.L. 登録日 2010-11-03 公開日 2011-11-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG to be published
3G0S	Dihydrodipicolinate synthase from Salmonella typhimurium LT2 分子名称: CHLORIDE ION, Dihydrodipicolinate synthase, GLYCEROL, ... 著者 Osipiuk, J, Maltseva, N, Stam, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2009-01-28 公開日 2009-02-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 X-ray crystal structure of dihydrodipicolinate synthase from Salmonella typhimurium LT2. To be Published
2O8C	human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair 分子名称: 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*(6OG)P*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ... 著者 Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S. 登録日 2006-12-12 公開日 2007-06-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Structure of the Human MutSalpha DNA Lesion Recognition Complex. Mol.Cell, 26, 2007
3PJQ	Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose 分子名称: Trans-sialidase, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose 著者 Oppezzo, P, Baraibar, M, Obal, G, Pritsch, O, Alzari, P.M, Buschiazzo, A. 登録日 2010-11-10 公開日 2011-06-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim.Biophys.Acta, 1814, 2011
3G2G	S437Y Mutant of human muscle pyruvate kinase, isoform M2 分子名称: Pyruvate kinase isozymes M1/M2, SULFATE ION, UNKNOWN ATOM OR ION 著者 Hong, B, Dimov, S, Allali-Hassani, A, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, c, Weigelt, J, Bochkarev, A, Vedadi, M, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-01-31 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 S437Y Mutant of human muscle pyruvate kinase, isoform M2 To be Published
3UGJ	Formyl Glycinamide ribonucletide amidotransferase from Salmonella Typhimurum: Role of the ATP complexation and glutaminase domain in catalytic coupling 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase, ... 著者 Morar, M, Tanwar, A.S, Panjikar, S, Anand, R. 登録日 2011-11-02 公開日 2012-06-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: role of ATP complexation and the glutaminase domain in catalytic coupling Acta Crystallogr.,Sect.D, 68, 2012
3UUF	Crystal structure of mono- and diacylglycerol lipase from Malassezia globosa 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LIP1, secretory lipase (Family 3), ... 著者 Xu, T, Xu, J, Hou, S, Liu, J. 登録日 2011-11-28 公開日 2012-04-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J.Struct.Biol., 178, 2012
3PV5	Structure of Legionella fallonii DegQ (N189G/P190G variant) 分子名称: DegQ 著者 Wrase, R, Scott, H, Hilgenfeld, R, Hansen, G. 登録日 2010-12-06 公開日 2011-06-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies. Proc.Natl.Acad.Sci.USA, 108, 2011
2NXZ	HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, ... 著者 Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. 登録日 2006-11-20 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
2NRZ	Crystal structure of the C-terminal half of UvrC bound to its catalytic divalent cation 分子名称: MANGANESE (II) ION, UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
2NYA	Crystal structure of the periplasmic nitrate reductase (NAP) from Escherichia coli 分子名称: 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, MOLYBDENUM(VI) ION, ... 著者 Jepson, B.J.N, Richardson, D.J, Hemmings, A.M. 登録日 2006-11-20 公開日 2006-12-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Spectropotentiometric and structural analysis of the periplasmic nitrate reductase from Escherichia coli J.Biol.Chem., 282, 2007
3PVW	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A) 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Thal, D.M, Tesmer, J.J. 登録日 2010-12-07 公開日 2011-06-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol.Pharmacol., 80, 2011
2NT0	Acid-beta-glucosidase low pH, glycerol bound 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Glucosylceramidase, ... 著者 Lieberman, R.L, Petsko, G.A, Ringe, D. 登録日 2006-11-06 公開日 2006-12-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol., 3, 2007
3UI6	0.89 A resolution crystal structure of human Parvulin 14 in complex with oxidized DTT 分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, SODIUM ION, ... 著者 Mueller, J.W, Link, N.M, Matena, A, Hoppstock, L, Rueppel, A, Bayer, P, Blankenfeldt, W. 登録日 2011-11-04 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (0.89 Å) 主引用文献 0.89 A resolution crystal structure of human Parvulin 14 in complex with oxidized DTT To be Published
2O16	Crystal structure of a putative acetoin utilization protein (AcuB) from Vibrio cholerae 分子名称: Acetoin utilization protein AcuB, putative, PHOSPHATE ION 著者 Patskovsky, Y, Bonanno, J.B, Rutter, M, Bain, K.T, Powell, A, Slocombe, A, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2006-11-28 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of a putative acetoin utilization protein (AcuB) from Vibrio cholerae To be Published
3PX4	Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*AP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ... 著者 Wang, W, Beese, L.S. 登録日 2010-12-09 公開日 2011-10-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.582 Å) 主引用文献 Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis. Proc.Natl.Acad.Sci.USA, 108, 2011
3UJ4	Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor 分子名称: Inositol 1,4,5-trisphosphate receptor type 1, SULFATE ION 著者 Ikura, M, Seo, M.D, Ishiyama, N, Stathopulos, P. 登録日 2011-11-07 公開日 2012-02-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and functional conservation of key domains in InsP3 and ryanodine receptors. Nature, 483, 2012
3PNM	Crystal Structure of E.coli Dha kinase DhaK (H56A) 分子名称: PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK 著者 Shi, R, McDonald, L, Matte, A, Cygler, M, Ekiel, I, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) 登録日 2010-11-19 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proc.Natl.Acad.Sci.USA, 108, 2011
2NV9	The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase 分子名称: A207R protein, arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE 著者 Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A. 登録日 2006-11-11 公開日 2007-03-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity. Biochemistry, 46, 2007
3FYU	Crystal structure of acetyl xylan esterase from Bacillus pumilus obtained in presence of D-xylose and sodium acetate 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, Acetyl xylan esterase, ... 著者 Krastanova, I, Cassetta, A, Lamba, D. 登録日 2009-01-23 公開日 2010-01-26 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structural and functional studies of Bacillus pumilus acetyl xylan esterase To be Published

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