8PDE
| Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC4 deacetylase binding motif | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), HDAC4 (histone deacetylase 4) binding motif peptide:GSGEVKMKLQEFVLNKK, ... | 著者 | Chinellato, M, Carli, A, Perin, S, Mazzocato, Y, Biondi, B, Di Giorgio, E, Brancolini, C, Angelini, A, Cendron, L. | 登録日 | 2023-06-12 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436, 2024
|
|
7ND2
| Cryo-EM structure of the human FERRY complex | 分子名称: | Glutamine amidotransferase-like class 1 domain-containing protein 1, Protein phosphatase 1 regulatory subunit 21, Quinone oxidoreductase-like protein 1 | 著者 | Quentin, D, Klink, B.U, Raunser, S. | 登録日 | 2021-01-29 | 公開日 | 2022-03-02 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of mRNA binding by the human FERRY Rab5 effector complex. Mol.Cell, 83, 2023
|
|
7EK8
| |
6OL2
| Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | 分子名称: | ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ... | 著者 | Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J. | 登録日 | 2019-04-15 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening To Be Published
|
|
6LSE
| Crystal structure of the enterovirus 71 polymerase elongation complex (C3S6A/C3S6B form) | 分子名称: | Genome polyprotein, PYROPHOSPHATE 2-, RNA (35-MER), ... | 著者 | Wang, M, Shu, B, Jing, X, Gong, P. | 登録日 | 2020-01-17 | 公開日 | 2020-04-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
|
|
7N9S
| TcdB and frizzled-2 CRD complex | 分子名称: | Frizzled-2, Toxin B | 著者 | Jiang, M, Zhang, J. | 登録日 | 2021-06-18 | 公開日 | 2022-03-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
|
|
6EG7
| BbvCI B2 dimer with I3C clusters | 分子名称: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, BbvCI endonuclease subunit 2, ... | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2018-08-19 | 公開日 | 2018-11-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI. Nucleic Acids Res., 47, 2019
|
|
6UC3
| Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | 分子名称: | BIOTIN, Streptavidin | 著者 | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | 登録日 | 2019-09-13 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
|
|
7N9Y
| Full-length TcdB and CSPG4 (401-560) complex | 分子名称: | Chondroitin sulfate proteoglycan 4, Toxin B | 著者 | Jiang, M, Zhang, J. | 登録日 | 2021-06-18 | 公開日 | 2022-03-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
|
|
5I08
| Prefusion structure of a human coronavirus spike protein | 分子名称: | Spike glycoprotein,Foldon chimera | 著者 | Kirchdoerfer, R.N, Cottrell, C.A, Wang, N, Pallesen, J, Yassine, H.M, Turner, H.L, Corbett, K.S, Graham, B.S, McLellan, J.S, Ward, A.B. | 登録日 | 2016-02-03 | 公開日 | 2016-03-02 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Pre-fusion structure of a human coronavirus spike protein. Nature, 531, 2016
|
|
8SH2
| KLHDC2 in complex with EloB and EloC | 分子名称: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | 著者 | Digianantonio, K.M, Bekes, M. | 登録日 | 2023-04-13 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
|
|
8SQF
| OXA-48 bound to inhibitor CDD-2725 | 分子名称: | (1M)-3'-(benzyloxy)-5-hydroxy[1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, Beta-lactamase | 著者 | Park, S, Judge, A, Fan, J, Sankaran, B, Prasad, B.V.V, Palzkill, T. | 登録日 | 2023-05-04 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J.Med.Chem., 67, 2024
|
|
7N95
| state 1 of TcdB and FZD2 at pH5 | 分子名称: | Frizzled-2, Toxin B | 著者 | Jiang, M, Zhang, J. | 登録日 | 2021-06-16 | 公開日 | 2022-03-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
|
|
5DQK
| Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mg2+ | 分子名称: | MAGNESIUM ION, POTASSIUM ION, RNA (48-MER), ... | 著者 | Mir, A, Chen, J, Neau, D, Golden, B.L. | 登録日 | 2015-09-14 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.707 Å) | 主引用文献 | Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction. Biochemistry, 54, 2015
|
|
7N36
| |
7AO4
| Crystal structure of CotB2 variant W288G | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclooctat-9-en-7-ol synthase | 著者 | Dimos, N, Driller, R, Loll, B. | 登録日 | 2020-10-13 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol. J.Am.Chem.Soc., 142, 2020
|
|
7NAK
| Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD) | 分子名称: | NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T. | 登録日 | 2021-06-21 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022
|
|
6U8B
| |
7N39
| |
6EJZ
| Tryptophan Repressor TrpR from E.coli variant S88Y with Indole-3-acetic acid as ligand | 分子名称: | 1,2-ETHANEDIOL, 1H-INDOL-3-YLACETIC ACID, SULFATE ION, ... | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-24 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
|
|
7N3B
| |
5IA1
| Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with MLN8054 | 分子名称: | 1,2-ETHANEDIOL, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, Ephrin type-A receptor 2 | 著者 | Kudlinzki, D, Linhard, V.L, Gande, S.L, Sreeramulu, S, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | 登録日 | 2016-02-21 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.036 Å) | 主引用文献 | Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem. Biol., 11, 2016
|
|
5L44
| Structure of K-26-DCP in complex with the K-26 tripeptide | 分子名称: | K-26 dipeptidyl carboxypeptidase, MAGNESIUM ION, N-ACETYL-L-ILE-L-TYR-(R)-1-AMINO-2-(4-HYDROXYPHENYL)ETHYLPHOSPHONIC ACID, ... | 著者 | Masuyer, G, Acharya, K.R, Kramer, G.J, Bachmann, B.O. | 登録日 | 2016-05-24 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. FEBS J., 283, 2016
|
|
7NAL
| Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains) | 分子名称: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1 | 著者 | Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T. | 登録日 | 2021-06-21 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022
|
|
8SWK
| Cryo-EM structure of NLRP3 closed hexamer | 分子名称: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | 著者 | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | 登録日 | 2023-05-18 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | 主引用文献 | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
|
|