8PDE

Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC4 deacetylase binding motif

Summary for 8PDE

• Entry DOI: 10.2210/pdb8pde/pdb
• Descriptor: MEF2D protein, HDAC4 (histone deacetylase 4) binding motif peptide:GSGEVKMKLQEFVLNKK, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... (5 entities in total)
• Functional Keywords: myocyte enhancer factor 2, class ii histone deacetylase, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 66006.09

Authors

Chinellato, M.,Carli, A.,Perin, S.,Mazzocato, Y.,Biondi, B.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (deposition date: 2023-06-12, release date: 2024-04-17)

• Primary citation: Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A.; Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA.; J.Mol.Biol., 436:168541-168541, 2024; PubMed: 38492719; DOI: 10.1016/j.jmb.2024.168541

Experimental method

X-RAY DIFFRACTION (2.4 Å)