8SWK

Cryo-EM structure of NLRP3 closed hexamer

Summary for 8SWK

• Entry DOI: 10.2210/pdb8swk/pdb
• EMDB information: 40820
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
• Functional Keywords: closed nlrp3, cryo-em, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 627517.72

Authors

Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S. (deposition date: 2023-05-18, release date: 2024-02-14)

• Primary citation: Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S.; Cryo-EM structures of NLRP3 reveal its self-activation mechanism; Nat Commun, 2024

Experimental method

ELECTRON MICROSCOPY (4.32 Å)