8SWK
Cryo-EM structure of NLRP3 closed hexamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NACHT, LRR and PYD domains-containing protein 3 | polymer | 910 | 103676.6 | 6 | UniProt (Q96P20) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516) | Homo sapiens (human) | Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1 |
| 2 | G, I, K, M, O... (A, B, C, D, E...) | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea | non-polymer | 402.5 | 6 | Chemie (7YN) | |||
| 3 | H, J, L, N, P... (A, B, C, D, E...) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 6 | Chemie (ATP) |
Sequence modifications
A, B, C, D, E, F: 133 - 1036 (UniProt: Q96P20)
| PDB | External Database | Details |
|---|---|---|
| Ala 127 | - | expression tag |
| Glu 128 | - | expression tag |
| Tyr 129 | - | expression tag |
| Cys 130 | - | expression tag |
| Phe 131 | - | expression tag |
| Asn 132 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 622059.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5457.9 | |
| All* | Total formula weight | 627517.7 |
