PDB: 16941 件ウェブページステータス検索Chemie searchBIRD

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4ENH	Crystal Structure of Human Cytochrome P450 CYP46A1 with Fluvoxamine Bound 分子名称: Cholesterol 24-hydroxylase, Fluvoxamine, PROTOPORPHYRIN IX CONTAINING FE 著者 Stout, C.D, Mast, N, Pikuleva, I.A. 登録日 2012-04-13 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine. Mol.Pharmacol., 82, 2012
1B4M	NMR STRUCTURE OF APO CELLULAR RETINOL-BINDING PROTEIN II, 24 STRUCTURES 分子名称: CELLULAR RETINOL-BINDING PROTEIN II 著者 Lu, J, Lin, C.-L, Tang, C, Ponder, J.W, Kao, J.L.F, Cistola, D.P, Li, E. 登録日 1998-12-23 公開日 1999-04-27 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The structure and dynamics of rat apo-cellular retinol-binding protein II in solution: comparison with the X-ray structure. J.Mol.Biol., 286, 1999
5AP1	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 分子名称: 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile, DUAL SPECIFICITY PROTEIN KINASE TTK, GLYCEROL, ... 著者 Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. 登録日 2015-09-14 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
5AP0	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 分子名称: 1,2-ETHANEDIOL, 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE, DIMETHYL SULFOXIDE, ... 著者 Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. 登録日 2015-09-14 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
5AP5	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 分子名称: (2-hydroxyethoxy)acetaldehyde, 1,2-ETHANEDIOL, DUAL SPECIFICITY PROTEIN KINASE TTK, ... 著者 Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. 登録日 2015-09-14 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
6PF4	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase, [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)phenyl]acetic acid 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.854 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PF3	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-chlorobenzoic acid, Thymidylate synthase 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.391 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PF6	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid, Thymidylate synthase,Thymidylate synthase 著者 Czyzyk, D.L, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
7VED	Crystal structure of GABARAP fused to TEX264 LIR with S272D mutation 分子名称: SULFATE ION, Testis-expressed protein 264,Gamma-aminobutyric acid receptor-associated protein 著者 Yamasaki, A, Noda, N.N. 登録日 2021-09-08 公開日 2022-03-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins. Embo Rep., 23, 2022
2IYB	Structure of complex between the 3rd LIM domain of TES and the EVH1 domain of Mena 分子名称: PROTEIN ENABLED HOMOLOG, TESTIN, ZINC ION 著者 Briggs, D.C, McDonald, N.Q. 登録日 2006-07-14 公開日 2007-10-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol. Cell, 28, 2007
2NW4	Crystal Structure of the Rat Androgen Receptor Ligand Binding Domain Complex with BMS-564929 分子名称: 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE, Androgen receptor 著者 Ostrowski, J, Kuhns, J.E, Lupisella, J.A, Manfredi, M.C, Beehler, B.C, Krystek, S.R, Bi, Y, Sun, C, Seethala, R, Golla, R, Sleph, P.G, Fura, A, An, Y, Kish, K.F, Sack, J.S, Mookhtiar, K.A, Grover, G.J, Hamann, L.G. 登録日 2006-11-14 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology, 148, 2007
6H86	Rebuilt and re-refined PDB entry 4R3Q: Crystal structure of SYCE3 分子名称: Synaptonemal complex central element protein 3 著者 Davies, O.R. 登録日 2018-08-02 公開日 2019-05-08 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 A molecular model for self-assembly of the synaptonemal complex protein SYCE3. J.Biol.Chem., 294, 2019
6R17	Crystal structure of the SYCE2-TEX12 delta-Ctip 2:2 complex 分子名称: Synaptonemal complex central element protein 2, Testis-expressed protein 12 著者 Dunce, J.M, Salmon, L.J, Davies, O.R. 登録日 2019-03-13 公開日 2020-09-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.424 Å) 主引用文献 Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12. Nat.Struct.Mol.Biol., 28, 2021
6HK9	Crystal structure of TEX12 F102A F109E V116A 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, CALCIUM ION, ... 著者 Dunce, J.M, Salmon, L.J, Davies, O.R. 登録日 2018-09-06 公開日 2019-09-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.454 Å) 主引用文献 Synaptonemal complex central element extension through hierarchical assembly of SYCE2-TEX12 into alpha-fibres To Be Published
6HK8	Crystal structure of TEX12 delta-Ctip 分子名称: 1,4-DIETHYLENE DIOXIDE, Testis-expressed protein 12 著者 Salmon, L.J, Davies, O.R. 登録日 2018-09-06 公開日 2019-10-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.111 Å) 主引用文献 Synaptonemal complex central element extension through hierarchical assembly of SYCE2-TEX12 into alpha-fibres To Be Published
5TAR	Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II - with ordered hypervariable region) 分子名称: 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... 著者 Dharmaiah, S, Tran, T.H, Simanshu, D.K. 登録日 2016-09-10 公開日 2016-11-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta. Proc.Natl.Acad.Sci.USA, 113, 2016
6V41	crystal structure of CDY1 chromodomain bound to H3K9me3 分子名称: Histone H3.1 Peptide, Testis-specific chromodomain protein Y 1, UNKNOWN ATOM OR ION 著者 Qin, S, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) 登録日 2019-11-27 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
2N1G	Structure of C-terminal domain of human polymerase Rev1 in complex with PolD3 RIR-motif 分子名称: DNA polymerase delta subunit 3, DNA repair protein REV1 著者 Pustovalova, Y, Korzhnev, D. 登録日 2015-04-01 公開日 2016-04-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Pol zeta Suggests a Mechanism of Polymerase Exchange upon Rev1/Pol zeta-Dependent Translesion Synthesis. Biochemistry, 55, 2016
8FL3	Human nuclear pre-60S ribosomal subunit (State I2) 分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.53 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
8FL4	Human nuclear pre-60S ribosomal subunit (State I3) 分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
8FL2	Human nuclear pre-60S ribosomal subunit (State I1) 分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
6R2F	Crystal structure of TEX12 F102A F109E V116A in an alternative conformation 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Testis-expressed protein 12 著者 Dunce, J.M, Davies, O.R. 登録日 2019-03-17 公開日 2020-04-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Meiotic synaptonemal complex extension through fibrous assembly of SYCE2-TEX12 To Be Published
5TB5	Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region) 分子名称: 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... 著者 Dharmaiah, S, Tran, T.H, Simanshu, D.K. 登録日 2016-09-11 公開日 2016-11-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta. Proc.Natl.Acad.Sci.USA, 113, 2016
5TEG	Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine 分子名称: Histone H4 mutant peptide with H4K20norleucine, N-lysine methyltransferase KMT5A, S-ADENOSYLMETHIONINE 著者 Judge, R.A, Petros, A.M. 登録日 2016-09-21 公開日 2016-12-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. ACS Med Chem Lett, 7, 2016
2AMB	Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone 分子名称: 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Pereira de Jesus-Tran, K, Cote, P.-L, Cantin, L, Blanchet, J, Labrie, F, Breton, R. 登録日 2005-08-09 公開日 2006-05-16 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci., 15, 2006

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