PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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2OPQ	Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
1TV6	HIV-1 Reverse Transcriptase Complexed with CP-94,707 分子名称: 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE, reverse transcriptase p51 subunit, reverse transcriptase p66 subunit 著者 Pata, J.D, Stirtan, W.G, Goldstein, S.W, Steitz, T.A. 登録日 2004-06-28 公開日 2004-07-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors Proc.Natl.Acad.Sci.USA, 101, 2004
2OPP	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Chan, S.J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
7S76	HBV CAPSID Y132A WITH COMPOUND 10b AT 2.5A RESOLUTION 分子名称: (1-methyl-1H-1,2,4-triazol-3-yl)methyl {(4S)-1-[(3-chloro-4-fluorophenyl)carbamoyl]-2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol-4-yl}carbamate, Capsid protein 著者 Olland, A.M, Suto, R.K. 登録日 2021-09-15 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The identification of highly efficacious functionalised tetrahydrocyclopenta[ c ]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly. Rsc Med Chem, 13, 2022
7OXO	human LonP1, R-state, incubated in AMPPCP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. 登録日 2021-06-22 公開日 2021-12-22 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
6EY7	Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound 分子名称: 4-[(4-fluorophenyl)methyl-methyl-amino]-2,4-bis(oxidanylidene)butanoic acid, CHLORIDE ION, MANGANESE (II) ION, ... 著者 Bongarzone, S, Nadal, M, Kaczmarska, Z, Machon, C, Alvarez, M, Albericio, F, Coll, M. 登録日 2017-11-10 公開日 2018-10-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Driven Discovery of alpha , gamma-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase. Acs Omega, 3, 2018
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
1D0Q	STRUCTURE OF THE ZINC-BINDING DOMAIN OF BACILLUS STEAROTHERMOPHILUS DNA PRIMASE 分子名称: DNA PRIMASE, ZINC ION 著者 Pan, H, Wigley, D.B. 登録日 1999-09-14 公開日 2000-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase. Structure Fold.Des., 8, 2000
2C3S	Structure Of Sars Cov Main Proteinase At 1.9 A (Ph6.5) 分子名称: SARS COV 3C-LIKE PROTEINASE 著者 Xu, T, Ooi, A, Lee, H.-C, Lescar, J. 登録日 2005-10-12 公開日 2005-10-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Sars Coronavirus Main Proteinase as an Active C2 Crystallographic Dimer. Acta Crystallogr.,Sect.F, 61, 2005
5W9D	Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen 分子名称: Endoxifen, Estrogen receptor 著者 Fanning, S.W, Greene, G.L. 登録日 2017-06-23 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6464 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
5W9C	Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen 分子名称: 4-HYDROXYTAMOXIFEN, Estrogen receptor 著者 Fanning, S.W, Greene, G.W. 登録日 2017-06-23 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
1VSI	ASV INTEGRASE CORE DOMAIN WITH CA(II) COFACTOR 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, INTEGRASE 著者 Bujacz, G, Alexandratos, J, Wlodawer, A. 登録日 1997-03-04 公開日 1997-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J.Biol.Chem., 272, 1997
4ESV	A New Twist on the Translocation Mechanism of Helicases from the Structure of DnaB with its Substrates 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', 5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', ... 著者 Itsathitphaisarn, O, Wing, R.A, Eliason, W.K, Wang, J, Steitz, T.A. 登録日 2012-04-23 公開日 2012-10-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell(Cambridge,Mass.), 151, 2012
2X9N	High resolution structure of TbPTR1 in complex with cyromazine 分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, ACETATE ION, DITHIANE DIOL, ... 著者 Dawson, A, Tulloch, L.B, Barrack, K.L, Hunter, W.N. 登録日 2010-03-23 公開日 2010-06-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 High-Resolution Structures of Trypanosoma Brucei Pteridine Reductase Ligand Complexes Inform on the Placement of New Molecular Entities in the Active Site of a Potential Drug Target Acta Crystallogr.,Sect.D, 66, 2010
6CBZ	Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide 分子名称: ESTRADIOL, Estrogen receptor, GLYCEROL, ... 著者 Fanning, S.W, Greene, G.L. 登録日 2018-02-05 公開日 2018-02-28 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
1VYB	Endonuclease domain of human LINE1 ORF2p 分子名称: GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ... 著者 Weichenrieder, O, Repanas, K, Perrakis, A. 登録日 2004-04-25 公開日 2004-06-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure, 12, 2004
1VSH	ASV INTEGRASE CORE DOMAIN WITH ZN(II) COFACTORS 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, INTEGRASE, ZINC ION 著者 Bujacz, G, Alexandratos, J, Wlodawer, A. 登録日 1997-03-04 公開日 1997-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J.Biol.Chem., 272, 1997
1VSJ	ASV INTEGRASE CORE DOMAIN WITH CD(II) COFACTORS 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, INTEGRASE 著者 Bujacz, G, Alexandratos, J, Wlodawer, A. 登録日 1997-03-04 公開日 1997-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J.Biol.Chem., 272, 1997
1YTI	SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT 分子名称: PEPTIDE PRODUCT, SIV PROTEASE 著者 Rose, R.B, Craik, C.S, Douglas, N.L, Stroud, R.M. 登録日 1996-08-01 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry, 35, 1996
1YTG	SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT 分子名称: HIV PROTEASE, PEPTIDE PRODUCT 著者 Rose, R.B, Craik, C.S, Douglas, N.L, Stroud, R.M. 登録日 1996-08-01 公開日 1997-03-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry, 35, 1996
1YTJ	SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT 分子名称: PEPTIDE PRODUCT, SIV PROTEASE 著者 Rose, R.B, Craik, C.S, Douglas, N.L, Stroud, R.M. 登録日 1996-08-01 公開日 1997-03-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry, 35, 1996
1YTH	SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT 分子名称: HIV PROTEASE, PEPTIDE PRODUCT 著者 Rose, R.B, Craik, C.S, Douglas, N.L, Stroud, R.M. 登録日 1996-08-01 公開日 1997-03-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry, 35, 1996
1FMB	EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793 分子名称: EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL 著者 Wlodawer, A, Gustchina, A, Zdanov, A, Kervinen, J. 登録日 1996-02-27 公開日 1996-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of equine infectious anemia virus proteinase complexed with an inhibitor. Protein Sci., 5, 1996
8T7T	CryoEM structure of the HisRS-like domain of human GCN2 分子名称: eIF-2-alpha kinase GCN2 著者 Yin, J.Z, Keszei, A.F.A, Mazhab-Jafari, M.T, Sicheri, F. 登録日 2023-06-21 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 CryoEM structure of the HisRS-like domain of human GCN2 To Be Published
4DOZ	Crystal structure of Pyrococcus furiosus Cmr2 (Cas10) 分子名称: Putative uncharacterized protein, ZINC ION 著者 Zhu, X, Ye, K. 登録日 2012-02-12 公開日 2012-03-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of Cmr2 suggests a nucleotide cyclase-related enzyme in type III CRISPR-Cas systems Febs Lett., 586, 2012

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