PDB: 19326 件ウェブページステータス検索Chemie searchBIRD

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3G3J	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant with glutamate and NaCl at 1.32 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.321 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FXZ	Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172 分子名称: OCTAHEDRAL RU-PYRIDOCARBAZOLE, Serine/threonine-protein kinase PAK 1 著者 Maksimoska, J, Marmorstein, R, Meggers, E. 登録日 2009-01-21 公開日 2009-02-17 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes J.Am.Chem.Soc., 130, 2008
3HKL	Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Muscle, skeletal receptor tyrosine protein kinase 著者 Stiegler, A.L, Hubbard, S.R. 登録日 2009-05-24 公開日 2009-08-25 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J.Mol.Biol., 393, 2009
3HKB	Tubulin: RB3 Stathmin-like domain complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Dorleans, A, Gigant, B, Ravelli, R.B.G, Mailliet, P, Mikol, V, Knossow, M. 登録日 2009-05-23 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Variations in the colchicine-binding domain provide insight into the structural switch of tubulin Proc.Natl.Acad.Sci.USA, 106, 2009
3HKC	Tubulin-ABT751: RB3 stathmin-like domain complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Dorleans, A, Gigant, B, Ravelli, R.B.G, Mailliet, P, Mikol, V, Knossow, M. 登録日 2009-05-23 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Variations in the colchicine-binding domain provide insight into the structural switch of tubulin Proc.Natl.Acad.Sci.USA, 106, 2009
3HKE	Tubulin-T138067: RB3 stathmin-like domain complex 分子名称: 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Dorleans, A, Gigant, B, Ravelli, R.B.G, Mailliet, P, Mikol, V, Knossow, M. 登録日 2009-05-23 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Variations in the colchicine-binding domain provide insight into the structural switch of tubulin Proc.Natl.Acad.Sci.USA, 106, 2009
3HKD	Tubulin-TN16 : RB3 stathmin-like domain complex 分子名称: (3Z,5S)-5-benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Dorleans, A, Gigant, B, Ravelli, R.B.G, Mailliet, P, Mikol, V, Knossow, M. 登録日 2009-05-23 公開日 2009-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Variations in the colchicine-binding domain provide insight into the structural switch of tubulin Proc.Natl.Acad.Sci.USA, 106, 2009
3HLO	Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease 分子名称: 'covalent dimer' [Gly51/D-Ala51'] HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide 著者 Torbeev, V.Y, Kent, S.B.H. 登録日 2009-05-27 公開日 2011-07-27 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
5OOM	Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA 分子名称: 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... 著者 Brown, A, Rathore, S, Kimanius, D, Aibara, S, Bai, X.C, Rorbach, J, Amunts, A, Ramakrishnan, V. 登録日 2017-08-08 公開日 2017-09-13 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Structures of the human mitochondrial ribosome in native states of assembly. Nat. Struct. Mol. Biol., 24, 2017
3EZG	Crystal structure of E18Q DJ-1 with oxidized C106 分子名称: Protein DJ-1 著者 Lakshminarasimhan, M, Wilson, M.A. 登録日 2008-10-22 公開日 2008-12-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. J.Biol.Chem., 284, 2009
3IJ8	Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase 分子名称: (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... 著者 Li, C, Zhang, R, Withers, S.G, Brayer, G.D. 登録日 2009-08-04 公開日 2009-10-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
5N7D	MAGI-1 complexed with a RSK1 peptide 分子名称: CALCIUM ION, GLYCEROL, Membrane-associated guanylate kinase, ... 著者 Gogl, G, Nyitray, L. 登録日 2017-02-20 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Dynamic control of RSK complexes by phosphoswitch-based regulation. FEBS J., 285, 2018
5N92	Crystal Structure of Human IL-17AF 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17A, Interleukin-17F 著者 Rondeau, J.-M, Goepfert, A. 登録日 2017-02-24 公開日 2017-09-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. Sci Rep, 7, 2017
3IAW	Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution 分子名称: N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, [Gly51;Aib51'] 'covalent dimer' HIV-1 protease 著者 Torbeev, V.Y, Kent, S.B.H. 登録日 2009-07-14 公開日 2011-04-27 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
3IJ7	Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase 分子名称: 4-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosyl fluoride, 4-O-methyl-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... 著者 Li, C, Zhang, R, Withers, S.G, Brayer, G.D. 登録日 2009-08-03 公開日 2009-10-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
3G60	Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 分子名称: (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a 著者 Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. 登録日 2009-02-05 公開日 2009-03-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science, 323, 2009
3G3G	Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.303 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
5NXU	Complex structure with maltose of Providencia stuartii Omp-Pst1 porin 分子名称: CALCIUM ION, LAURYL DIMETHYLAMINE-N-OXIDE, Porin 1, ... 著者 Colletier, J.P, Nasrallah, C. 登録日 2017-05-10 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Porin self-association enables cell-to-cell contact in Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3GES	Crystal structure of the guanine riboswitch C74U mutant bound to 6-O-methylguanine 分子名称: 6-O-methylguanine, ACETATE ION, COBALT HEXAMMINE(III), ... 著者 Gilbert, S.D, Batey, R.T. 登録日 2009-02-26 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Adaptive ligand binding by the purine riboswitch in the recognition of Guanine and adenine analogs Structure, 17, 2009
3HBO	Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease 分子名称: N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, [D-Ala51/51']HIV-1 protease 著者 Torbeev, V.Y, Kent, S.B.H. 登録日 2009-05-04 公開日 2010-05-26 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
3H6G	Crystal structure of the GluR6 amino terminal domain dimer assembly 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2009-04-23 公開日 2009-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.697 Å) 主引用文献 The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Nat.Struct.Mol.Biol., 16, 2009
3GSL	Crystal structure of PSD-95 tandem PDZ domains 1 and 2 分子名称: Disks large homolog 4 著者 Sainlos, M, Olivier, N.B, Imperiali, B. 登録日 2009-03-27 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization. Nat.Chem.Biol., 7, 2011
5NHF	Human Erk2 with an Erk1/2 inhibitor 分子名称: 2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-5-(phenylmethyl)-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-21 公開日 2017-04-19 最終更新日 2017-05-10 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHJ	Human Erk2 with an Erk1/2 inhibitor 分子名称: 5-(2-methoxyethyl)-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-21 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHP	Human Erk2 with an Erk1/2 inhibitor 分子名称: 5-(2-methoxyethyl)-1-methyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-22 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017

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