2YAC
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![BU of 2yac by Molmil](/molmil-images/mine/2yac) | Crystal structure of Polo-like kinase 1 in complex with NMS-P937 | 分子名称: | 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE, L(+)-TARTARIC ACID, SERINE/THREONINE-PROTEIN KINASE PLK1, ... | 著者 | Bertrand, J.A, Bossi, R.T. | 登録日 | 2011-02-18 | 公開日 | 2011-04-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Nms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor. Bioorg.Med.Chem.Lett., 21, 2011
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4WCI
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![BU of 4wci by Molmil](/molmil-images/mine/4wci) | Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3 | 分子名称: | CD2-associated protein, Ras and Rab interactor 3, SULFATE ION | 著者 | Rouka, E, Simister, P.C, Janning, M, Kirsch, K.H, Krojer, T, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC) | 登録日 | 2014-09-04 | 公開日 | 2015-08-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). J.Biol.Chem., 290, 2015
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2G3R
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![BU of 2g3r by Molmil](/molmil-images/mine/2g3r) | Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution | 分子名称: | SULFATE ION, Tumor suppressor p53-binding protein 1 | 著者 | Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G. | 登録日 | 2006-02-20 | 公開日 | 2007-01-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell(Cambridge,Mass.), 127, 2006
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2G99
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2G9N
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![BU of 2g9n by Molmil](/molmil-images/mine/2g9n) | Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A | 分子名称: | Eukaryotic initiation factor 4A-I | 著者 | Hogbom, M, Ogg, D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | 登録日 | 2006-03-07 | 公開日 | 2006-03-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Comparative Structural Analysis of Human DEAD-Box RNA Helicases. Plos One, 5, 2010
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8SYP
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![BU of 8syp by Molmil](/molmil-images/mine/8syp) | Genomic CX3CR1 nucleosome | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2023-05-25 | 公開日 | 2023-11-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
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8TGP
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8U17
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![BU of 8u17 by Molmil](/molmil-images/mine/8u17) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | 著者 | Clifton, M.C, Ma, X, Ornelas, E. | 登録日 | 2023-08-30 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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8U14
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![BU of 8u14 by Molmil](/molmil-images/mine/8u14) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXV
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![BU of 8txv by Molmil](/molmil-images/mine/8txv) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXX
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![BU of 8txx by Molmil](/molmil-images/mine/8txx) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 3) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UPF
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![BU of 8upf by Molmil](/molmil-images/mine/8upf) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-10-22 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U13
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![BU of 8u13 by Molmil](/molmil-images/mine/8u13) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXW
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![BU of 8txw by Molmil](/molmil-images/mine/8txw) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 2) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UIS
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![BU of 8uis by Molmil](/molmil-images/mine/8uis) | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Su, B.G, Vos, S.M. | 登録日 | 2023-10-10 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
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8W9E
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8W8F
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![BU of 8w8f by Molmil](/molmil-images/mine/8w8f) | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | 分子名称: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | 著者 | Li, Y, Wang, Q, Xu, Y, Li, Z. | 登録日 | 2023-09-02 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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8W9D
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8X73
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![BU of 8x73 by Molmil](/molmil-images/mine/8x73) | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | 分子名称: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | 著者 | Zhang, H, Luo, C. | 登録日 | 2023-11-22 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8X71
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![BU of 8x71 by Molmil](/molmil-images/mine/8x71) | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | 分子名称: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | 著者 | Zhang, H, Luo, C. | 登録日 | 2023-11-22 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8WAP
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![BU of 8wap by Molmil](/molmil-images/mine/8wap) | Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (5.85 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAS
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![BU of 8was by Molmil](/molmil-images/mine/8was) | Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (6.13 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAN
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![BU of 8wan by Molmil](/molmil-images/mine/8wan) | Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-07 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (6.07 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAL
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![BU of 8wal by Molmil](/molmil-images/mine/8wal) | Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II positioned 3nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-07 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (8.52 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAQ
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![BU of 8waq by Molmil](/molmil-images/mine/8waq) | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II positioned 7nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (6.29 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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