8U14

Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2)

Summary for 8U14

Entry DOI	10.2210/pdb8u14/pdb
EMDB information	41800 41801
Descriptor	Histone H3.1, Histone H4, Histone H2B type 1-J, ... (9 entities in total)
Functional Keywords	nucleosome core particle, chromatin, rnf168, ubch5c, dna repair, dna double-strand break, homologous recombination, brca1-bard1, 53bp1, ubiquitin, structural protein-dna-transferase complex, structural protein/dna/transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	227987.33
Authors	Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, G. (deposition date: 2023-08-30, release date: 2024-01-17, Last modification date: 2024-03-20)
Primary citation	Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84:839-853.e12, 2024 Cited by PubMed: 38242129 DOI: 10.1016/j.molcel.2023.12.036 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation