7ZZO
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![BU of 7zzo by Molmil](/molmil-images/mine/7zzo) | HDAC2 in complex with an inhibitor | 分子名称: | 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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5GY2
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3HLC
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![BU of 3hlc by Molmil](/molmil-images/mine/3hlc) | Simvastatin Synthase (LovD) from Aspergillus terreus, S5 mutant, unliganded | 分子名称: | GLYCEROL, TETRAETHYLENE GLYCOL, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Laidman, J, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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7ZZT
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![BU of 7zzt by Molmil](/molmil-images/mine/7zzt) | Ligand binding to HDAC2 | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZP
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![BU of 7zzp by Molmil](/molmil-images/mine/7zzp) | Structure of HDAC2 complexed with an inhibitory ligand | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZR
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![BU of 7zzr by Molmil](/molmil-images/mine/7zzr) | HDAC2 in complex with inhibitory ligand | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.168 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZW
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![BU of 7zzw by Molmil](/molmil-images/mine/7zzw) | Ligand binding to HDAC2 | 分子名称: | 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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8A0B
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![BU of 8a0b by Molmil](/molmil-images/mine/8a0b) | Inhibitor binding to HDAC2 | 分子名称: | 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-27 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.746 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZS
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![BU of 7zzs by Molmil](/molmil-images/mine/7zzs) | HDAC2 complexed with an inhibitory ligand | 分子名称: | (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZU
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![BU of 7zzu by Molmil](/molmil-images/mine/7zzu) | Inhibitory Ligand binding to HDAC2 | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | 著者 | Cleasby, A, Tisi, D. | 登録日 | 2022-05-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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5GS4
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![BU of 5gs4 by Molmil](/molmil-images/mine/5gs4) | Crystal structure of estrogen receptor alpha in complex with a stabilized peptide antagonist | 分子名称: | ARG-IAS-ILE-LEU-DNP-ARG-LEU-LEU-GLN, ESTRADIOL, Estrogen receptor, ... | 著者 | Xie, M, Wang, T, Li, Z.-G. | 登録日 | 2016-08-13 | 公開日 | 2017-08-30 | 最終更新日 | 2018-07-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides J. Med. Chem., 60, 2017
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2KOW
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6GQB
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![BU of 6gqb by Molmil](/molmil-images/mine/6gqb) | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | 著者 | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | 登録日 | 2018-06-07 | 公開日 | 2018-07-11 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance. J. Mol. Biol., 430, 2018
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8BXA
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![BU of 8bxa by Molmil](/molmil-images/mine/8bxa) | Crystal structure of ribosome binding factor A (RbfA) from S. aureus | 分子名称: | Ribosome-binding factor A | 著者 | Fatkhullin, B, Bikmullin, A, Gabdulkhakov, A, Khusainov, I, Validov, S, Usachev, K, Yusupov, M. | 登録日 | 2022-12-08 | 公開日 | 2023-02-22 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Yet Another Similarity between Mitochondrial and Bacterial Ribosomal Small Subunit Biogenesis Obtained by Structural Characterization of RbfA from S. aureus. Int J Mol Sci, 24, 2023
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6EQ8
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5FHF
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![BU of 5fhf by Molmil](/molmil-images/mine/5fhf) | Crystal structure of Bacteroides sp Pif1 in complex with ADP-AlF4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, Uncharacterized protein | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
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6NS0
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![BU of 6ns0 by Molmil](/molmil-images/mine/6ns0) | |
5DO9
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![BU of 5do9 by Molmil](/molmil-images/mine/5do9) | |
5HDS
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6NI5
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6NI6
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1BYJ
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![BU of 1byj by Molmil](/molmil-images/mine/1byj) | GENTAMICIN C1A A-SITE COMPLEX | 分子名称: | 2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose, 3,5-DIAMINO-CYCLOHEXANOL, 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranose, ... | 著者 | Yoshizawa, S, Fourmy, D, Puglisi, J.D. | 登録日 | 1998-10-16 | 公開日 | 1999-10-29 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural origins of gentamicin antibiotic action. EMBO J., 17, 1998
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6NLL
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![BU of 6nll by Molmil](/molmil-images/mine/6nll) | 1.80 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 14) | 分子名称: | 4-{[3-(2,4-dihydroxyphenyl)propyl]amino}-1H-isoindole-1,3(2H)-dione, FE (II) ION, Ferroxidase, ... | 著者 | Lovell, S, Punchi-Hewage, A, Battaile, K.P, Yao, H, Nammalwar, B, Gnanasekaran, K.K, Bunce, R.A, Reitz, A.B, Rivera, M. | 登録日 | 2019-01-08 | 公開日 | 2019-05-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J.Am.Chem.Soc., 141, 2019
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3PET
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3LLC
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![BU of 3llc by Molmil](/molmil-images/mine/3llc) | |