5GS4
Crystal structure of estrogen receptor alpha in complex with a stabilized peptide antagonist
Summary for 5GS4
Entry DOI | 10.2210/pdb5gs4/pdb |
Descriptor | Estrogen receptor, ARG-IAS-ILE-LEU-DNP-ARG-LEU-LEU-GLN, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | estrogen receptor alpha, stabilized peptide, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29327.37 |
Authors | |
Primary citation | Xie, M.,Zhao, H.,Liu, Q.,Zhu, Y.,Yin, F.,Liang, Y.,Jiang, Y.,Wang, D.,Hu, K.,Qin, X.,Wang, Z.,Wu, Y.,Xu, N.,Ye, X.,Wang, T.,Li, Z. Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides J. Med. Chem., 60:8731-8740, 2017 Cited by PubMed: 29045135DOI: 10.1021/acs.jmedchem.7b00732 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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