5GS4
Crystal structure of estrogen receptor alpha in complex with a stabilized peptide antagonist
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 601 |
| Chain | Residue |
| A | HIS356 |
| A | ASN359 |
| A | ARG363 |
| A | HOH712 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 602 |
| Chain | Residue |
| A | LEU327 |
| A | ARG352 |
| A | HIS356 |
| A | HOH727 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue EST A 603 |
| Chain | Residue |
| A | LEU346 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | HIS524 |
| A | LEU525 |
| A | HOH750 |
| A | MET343 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residues IAS B 2 and DNP B 5 |
| Chain | Residue |
| A | LYS416 |
| A | GLU542 |
| B | ARG1 |
| B | ILE3 |
| B | LEU4 |
| B | ARG6 |
| B | LEU7 |
| B | LEU8 |
| B | GLN9 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 |
