1LT8
 
 | | Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine | | 分子名称: | BETAINE-HOMOCYSTEINE METHYLTRANSFERASE, CITRIC ACID, S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE, ... | | 著者 | Evans, J.C, Huddler, D.P, Jiracek, J, Castro, C, Millian, N.S, Garrow, T.A, Ludwig, M.L. | | 登録日 | 2002-05-20 | | 公開日 | 2002-09-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Betaine-homocysteine methyltransferase: zinc in a distorted barrel.
Structure, 10, 2002
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5OWC
 | | Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors | | 分子名称: | 3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic acid, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sandmark, J.S, Roth, R.G, Knerr, L, Bodin, C, Pettersen, D. | | 登録日 | 2017-08-31 | | 公開日 | 2018-08-01 | | 最終更新日 | 2021-05-05 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2Type X (sPLA2-X) Inhibitors.
Acs Med.Chem.Lett., 9, 2018
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6EQ2
 | | MTH1 in complex with fragment 6 | | 分子名称: | 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
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6EQ7
 | | MTH1 in complex with fragment 11 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION | | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
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5OQF
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5OQL
 | | Cryo-EM structure of the 90S pre-ribosome from Chaetomium thermophilum | | 分子名称: | 35S rRNA, 40S ribosomal protein S1, 40S ribosomal protein S11-like protein, ... | | 著者 | Cheng, J, Kellner, N, Berninghausen, O, Hurt, E, Beckmann, R. | | 登録日 | 2017-08-12 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | 3.2- angstrom -resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
Nat. Struct. Mol. Biol., 24, 2017
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6RMW
 | | Structure of N-terminal truncated IMP bound Plasmodium falciparum IMP-nucleotidase | | 分子名称: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | | 登録日 | 2019-05-07 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Nat Commun, 11, 2020
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6RQC
 | | Cryo-EM structure of an MCM loading intermediate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... | | 著者 | Miller, T.C.R, Locke, J, Costa, A. | | 登録日 | 2019-05-15 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
Nature, 575, 2019
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7WXE
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6RMO
 | | Structure of Plasmodium falciparum IMP-nucleotidase | | 分子名称: | IMP-specific 5'-nucleotidase, putative | | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | | 登録日 | 2019-05-07 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Nat Commun, 11, 2020
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6RXU
 | | Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1 | | 分子名称: | 35S rRNA, 40S ribosomal protein S1, 40S ribosomal protein S11-like protein, ... | | 著者 | Cheng, J, Kellner, N, Griesel, S, Berninghausen, O, Beckmann, R, Hurt, E. | | 登録日 | 2019-06-10 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Mol.Cell, 75, 2019
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1KQK
 | | Solution Structure of the N-terminal Domain of a Potential Copper-translocating P-type ATPase from Bacillus subtilis in the Cu(I)loaded State | | 分子名称: | COPPER (I) ION, POTENTIAL COPPER-TRANSPORTING ATPASE | | 著者 | Banci, L, Bertini, I, Ciofi-Baffoni, S, D'Onofrio, M, Gonnelli, L, Marhuenda-Egea, F.C, Ruiz-Duenas, F.J. | | 登録日 | 2002-01-07 | | 公開日 | 2002-04-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states.
J.Mol.Biol., 317, 2002
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6EQ3
 | | MTH1 in complex with fragment 9 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol | | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
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6EQ5
 | | MTH1 in complex with fragment 4 | | 分子名称: | 1H-benzimidazol-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | | 著者 | Wiedmer, L, Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
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7UBM
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7UBN
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8J9D
 | | Crystal structure of M61 peptidase (bestatin-bound) from Xanthomonas campestris | | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | | 著者 | Yadav, P, Kumar, A, Kulkarni, B.S, Jamdar, S.N, Makde, R.D. | | 登録日 | 2023-05-03 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of a newly identified M61 family aminopeptidase with broad substrate specificity that is solely responsible for recycling acidic amino acids.
Febs J., 291, 2024
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7U6D
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5NSR
 | | Cryo-EM structure of RNA polymerase-sigma54 holo enzyme with promoter DNA closed complex | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Glyde, R, Ye, F.Z, Darbari, V.C, Zhang, N, Buck, M, Zhang, X.D. | | 登録日 | 2017-04-26 | | 公開日 | 2017-06-28 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation.
Mol. Cell, 67, 2017
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6RME
 | | Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N | | 分子名称: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | | 登録日 | 2019-05-06 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Nat Commun, 11, 2020
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1LT7
 | | Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions | | 分子名称: | BETAINE-HOMOCYSTEINE METHYLTRANSFERASE, CITRIC ACID, SAMARIUM (III) ION | | 著者 | Evans, J.C, Huddler, D.P, Jiracek, J, Castro, C, Millian, N.S, Garrow, T.A, Ludwig, M.L. | | 登録日 | 2002-05-20 | | 公開日 | 2002-09-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Betaine-homocysteine methyltransferase: zinc in a distorted barrel.
Structure, 10, 2002
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6RLQ
 | | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ45031882 | | 分子名称: | (1~{S},2~{R},3~{S},5~{R})-3-[2-(2-azanyl-3-bromanyl-quinolin-7-yl)ethyl]-5-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)cyclop entane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | 著者 | Brown, D.G, Robinson, C.M, Pande, V. | | 登録日 | 2019-05-02 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ45031882
To Be Published
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6RXT
 | | Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state A | | 分子名称: | 35S ribosomal RNA, 40S ribosomal protein S1, 40S ribosomal protein S13-like protein, ... | | 著者 | Cheng, J, Kellner, N, Griesel, S, Berninghausen, O, Beckmann, R, Hurt, E. | | 登録日 | 2019-06-10 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.
Mol.Cell, 75, 2019
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1LK2
 | | 1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Luz, J.G, Rudolph, M.G, Wilson, I.A, Eisen, H. | | 登録日 | 2002-04-23 | | 公開日 | 2003-11-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
J.Immunol., 172, 2004
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1L5X
 | | The 2.0-Angstrom resolution crystal structure of a survival protein E (SurE) homolog from Pyrobaculum aerophilum | | 分子名称: | ACETIC ACID, GLYCEROL, Survival protein E | | 著者 | Mura, C, Katz, J.E, Clarke, S.G, Eisenberg, D. | | 登録日 | 2002-03-08 | | 公開日 | 2003-02-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and Function of an Archaeal Homolog of Survival
Protein E (SurE-alpha): An Acid Phosphatase with Purine
Nucleotide Specificity
J.Mol.Biol., 326, 2003
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