PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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4BNC	Crystal structure of the DNA-binding domain of human ETV1 complexed with DNA 分子名称: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', HUMAN ETV1 著者 Allerston, C.K, Cooper, C.D.O, Krojer, T, Chaikuad, A, Vollmar, M, Froese, D.S, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O. 登録日 2013-05-14 公開日 2013-07-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. J.Biol.Chem., 290, 2015
4BVA	Crystal structure of the NADPH-T3 form of mouse Mu-crystallin. 分子名称: 3,5,3'TRIIODOTHYRONINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... 著者 Borel, F, Hachi, I, Palencia, A, Gaillard, M.C, Ferrer, J.L. 登録日 2013-06-25 公開日 2014-02-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of Mouse Mu-Crystallin Complexed with Nadph and the T3 Thyroid Hormone FEBS J., 281, 2014
4BV9	Crystal structure of the NADPH form of mouse Mu-crystallin. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Borel, F, Hachi, I, Palencia, A, Gaillard, M.C, Ferrer, J.L. 登録日 2013-06-25 公開日 2014-02-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.193 Å) 主引用文献 Crystal Structure of Mouse Mu-Crystallin Complexed with Nadph and the T3 Thyroid Hormone FEBS J., 281, 2014
4BQA	Crystal structure of the ETS domain of human ETS2 in complex with DNA 分子名称: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', PROTEIN C-ETS-2 著者 Newman, J.A, Cooper, C.D.O, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O. 登録日 2013-05-30 公開日 2013-06-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Insights Into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2. J.Biol.Chem., 290, 2015
4C05	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH 分子名称: PROTEIN ARGININE N-METHYLTRANSFERASE 6, S-ADENOSYL-L-HOMOCYSTEINE 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.195 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4BCG	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, ... 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-04-17 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (3.085 Å) 主引用文献 Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities. J.Med.Chem., 56, 2013
4BCO	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-01-09 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
4BCN	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
4BCM	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-03-06 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
4D1Z	CDK2 in complex with a Luciferin derivate 分子名称: (4S)-2-(8-hydroxyquinolin-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, CYCLIN-DEPENDENT KINASE 2 著者 Rothweiler, U, Engh, R.A. 登録日 2014-05-05 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Luciferin and Derivatives as a Dyrk Selective Scaffold for the Design of Protein Kinase Inhibitors. Eur.J.Med.Chem., 94, 2015
4CQF	Crystal structure of Schistosoma mansoni HDAC8 complexed with a mercaptoacetamide inhibitor 分子名称: 6-(2-Mercaptoacetylamino)-N-phenylhexanamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Marek, M, Romier, C. 登録日 2014-02-14 公開日 2014-04-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular Basis for the Anti-Parasitic Activity of a Mercaptoacetamide Derivative that Inhibits Histone Deacetylase 8 (Hdac8) from the Human Pathogen Schistosoma Mansoni J.Mol.Biol., 426, 2014
4BVU	Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate 分子名称: PROTEIN KINASE OSPG, UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2 D3 著者 Pruneda, J.N, LeTrong, I, Stenkamp, R.E, Klevit, R.E, Brzovic, P.S. 登録日 2013-06-28 公開日 2014-01-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 E2~Ub Conjugates Regulate the Kinase Activity of Shigella Effector Ospg During Pathogenesis. Embo J., 33, 2014
4C04	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with inhibitor 分子名称: PROTEIN ARGININE N-METHYLTRANSFERASE 6, SINEFUNGIN 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.576 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4C07	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.5 Angstroms 分子名称: CALCIUM ION, PROTEIN ARGININE N-METHYLTRANSFERASE 6 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4AWL	The NF-Y transcription factor is structurally and functionally a sequence specific histone 分子名称: HSP70 PROMOTER FRAGMENT, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, ... 著者 Nardini, M, Gnesutta, N, Donati, G, Gatta, R, Forni, C, Fossati, A, Vonrhein, C, Moras, D, Romier, C, Mantovani, R, Bolognesi, M. 登録日 2012-06-04 公開日 2013-01-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Sequence-Specific Transcription Factor NF-Y Displays Histone-Like DNA Binding and H2B-Like Ubiquitination. Cell(Cambridge,Mass.), 152, 2013
4CSR	High resolution crystal structure of the histone fold dimer (NF-YB)-(NF-YC) 分子名称: GLYCEROL, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA 著者 Gnesutta, N, Cocolo, S, Mantovani, R, Bolognesi, M, Nardini, M. 登録日 2014-03-09 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High Resolution Crystal Structure of the Histone Fold Dimer (NF-Yb)-(NF-Yc) To be Published
7SUV	APE1 exonuclease substrate complex with 8oxoG opposite A 分子名称: DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... 著者 Whitaker, A.W, Freudenthal, B.D. 登録日 2021-11-18 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Processing oxidatively damaged bases at DNA strand breaks by APE1. Nucleic Acids Res., 50, 2022
7SVB	APE1 exonuclease substrate complex with 8oxoG opposite C 分子名称: DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(8OG))-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... 著者 Whitaker, A.W, Freudenthal, B.D. 登録日 2021-11-18 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Processing oxidatively damaged bases at DNA strand breaks by APE1. Nucleic Acids Res., 50, 2022
4AMS	A Megaviridae ORFan gene encode a new nucleotidyl transferase 分子名称: MAGNESIUM ION, MG662 著者 Lartigue, A, Claverie, J.M, Priet, S, Abergel, C. 登録日 2012-03-13 公開日 2013-03-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A Megaviridae Orphan Gene Encodes a New Nucleotidyl Transferase To be Published
4A0L	Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex 分子名称: 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ... 著者 Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. 登録日 2011-09-09 公開日 2011-12-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (7.4 Å) 主引用文献 The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
4CO8	Structure of the DNA binding ETS domain of human ETV4 分子名称: 1,2-ETHANEDIOL, ETS TRANSLOCATION VARIANT 4 著者 Newman, J.A, Cooper, C.D.O, Shrestha, L, Burgess-Brown, N, Kopec, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. 登録日 2014-01-27 公開日 2014-02-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. J.Biol.Chem., 290, 2015
4AGH	Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae 分子名称: MOSUB1, TRANSCRIPTION COFACTOR 著者 Huang, J, Zhao, Y, Huang, D, liu, J, Peng, Y. 登録日 2012-01-27 公開日 2012-08-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.787 Å) 主引用文献 Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae. Acta Crystallogr.,Sect.D, 68, 2012
4AVP	Crystal structure of the DNA-binding domain of human ETV1. 分子名称: 1,2-ETHANEDIOL, ETS TRANSLOCATION VARIANT 1 著者 Allerston, C.K, Cooper, C.D.O, Krojer, T, Chaikuad, A, Filippakopoulos, P, Canning, P, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O. 登録日 2012-05-28 公開日 2012-06-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. J.Biol.Chem., 290, 2015
4CZZ	Histone demethylase LSD1(KDM1A)-CoREST3 Complex 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3 著者 Barrios, A.P, Gomez, A.V, Saez, J.E, Ciossani, G, Toffolo, E, Battaglioli, E, Mattevi, A, Andres, M.E. 登録日 2014-04-23 公開日 2014-06-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Differential Properties of Transcriptional Complexes Formed by the Corest Family. Mol.Cell.Biol., 34, 2014
4D1X	CDK2 in complex with Luciferin 分子名称: (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, CYCLIN-DEPENDENT KINASE 2 著者 Rothweiler, U, Engh, R.A. 登録日 2014-05-05 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Luciferin and Derivatives as a Dyrk Selective Scaffold for the Design of Protein Kinase Inhibitors. Eur.J.Med.Chem., 94, 2015

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