4BCN
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Summary for 4BCN
Entry DOI | 10.2210/pdb4bcn/pdb |
Related | 4BCF 4BCG 4BCH 4BCI 4BCJ 4BCK 4BCM 4BCO 4BCP 4BCQ |
Descriptor | CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ... (6 entities in total) |
Functional Keywords | transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design, transferase/cell cycle |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm, cytoskeleton, centrosome: P24941 Nucleus: P20248 P20248 |
Total number of polymer chains | 4 |
Total formula weight | 129384.56 |
Authors | Hole, A.J.,Baumli, S.,Wang, S.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-02, release date: 2013-03-06) |
Primary citation | Hole, A.J.,Baumli, S.,Shao, H.,Shi, S.,Pepper, C.,Fischer, P.M.,Wang, S.,Endicott, J.A.,Noble, M.E.M. Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56:660-, 2013 Cited by PubMed: 23252711DOI: 10.1021/JM301495V PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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