4BCN

Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CYCLIN-DEPENDENT KINASE 2	polymer	300	34200.6	2	UniProt (P24941) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE
2	B	CYCLIN-A2	polymer	262	30078.8	1	UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB	HOMO SAPIENS (HUMAN)	CYCLIN-A
3	D	CYCLIN-A2	polymer	262	30035.7	1	UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB	HOMO SAPIENS (HUMAN)	CYCLIN-A
4	A, C	2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	non-polymer		338.4	2	Chemie (T9N)
5	B, D	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6		water	water		18.0	687	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

B: 171 - 432 (UniProt: P20248)

PDB	External Database	Details
Ala 357	Gly 357	conflict
Leu 392	Met 392	conflict
Arg 400	Lys 400	conflict
Lys 403	Gln 403	conflict

D: 171 - 431 (UniProt: P20248)

PDB	External Database	Details
Val 432	-	expression tag
Ala 357	Gly 357	conflict
Leu 392	Met 392	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128515.7
Non-Polymers*	Number of molecules	4
	Total formula weight	868.9
All*	Total formula weight	129384.6

*Water molecules are not included.