4BCN
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | CYCLIN-DEPENDENT KINASE 2 | polymer | 300 | 34200.6 | 2 | UniProt (P24941) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE |
| 2 | B (B) | CYCLIN-A2 | polymer | 262 | 30078.8 | 1 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | HOMO SAPIENS (HUMAN) | CYCLIN-A |
| 3 | D (D) | CYCLIN-A2 | polymer | 262 | 30035.7 | 1 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | HOMO SAPIENS (HUMAN) | CYCLIN-A |
| 4 | E, G (A, C) | 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile | non-polymer | 338.4 | 2 | Chemie (T9N) | |||
| 5 | F, H (B, D) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B: 171 - 432 (UniProt: P20248)
D: 171 - 431 (UniProt: P20248)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 357 | Gly 357 | conflict |
| Leu 392 | Met 392 | conflict |
| Arg 400 | Lys 400 | conflict |
| Lys 403 | Gln 403 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 432 | - | expression tag |
| Ala 357 | Gly 357 | conflict |
| Leu 392 | Met 392 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128515.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 868.9 | |
| All* | Total formula weight | 129384.6 |
