PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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6ZYJ	Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Yan, Y, Preissler, S, Ron, D. 登録日 2020-08-01 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7A4V	Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ... 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
6ZYH	Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and calcium 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Endoplasmic reticulum chaperone BiP 著者 Yan, Y, Preissler, S, Ron, D. 登録日 2020-08-01 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7A4U	Crystal structure of lid-truncated apo BiP in an oligomeric state 分子名称: Endoplasmic reticulum chaperone BiP, GLYCEROL 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
4JN4	Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q. 登録日 2013-03-14 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol., 20, 2013
4JWI	Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(35-43) 分子名称: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2013-03-27 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4JWC	Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16) 分子名称: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2013-03-27 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4JWE	Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(1-21) 分子名称: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2013-03-27 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4JWD	Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(15-28) 分子名称: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION 著者 Zahn, M, Straeter, N. 登録日 2013-03-27 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4JNE	Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Hsp70 CHAPERONE DnaK, ... 著者 Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q. 登録日 2013-03-15 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol., 20, 2013
5AQX	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
4JNF	Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP 分子名称: Hsp70 CHAPERONE DnaK 著者 Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q. 登録日 2013-03-15 公開日 2013-05-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.621 Å) 主引用文献 Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol., 20, 2013
4J8F	Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, Hsc70-interacting protein, ... 著者 Li, Z, Bracher, A. 登録日 2013-02-14 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Nat.Struct.Mol.Biol., 20, 2013
5AQY	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 1,2-ETHANEDIOL, ADENOSINE, DIMETHYL SULFOXIDE, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
4KBO	Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form 分子名称: SODIUM ION, Stress-70 protein, mitochondrial 著者 Amick, J, Page, R.C, Nix, J.C, Misra, S. 登録日 2013-04-23 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci., 23, 2014
5BPM	Crystal structure of unhydrolyzed ATP bound human Hsp70 NBD double mutant E268Q+R272K. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-28 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BPL	Crystal structure of ADP and Pi bound human Hsp70 NBD mutant R272K. 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Narayanan, D, Engh, R.A. 登録日 2015-05-28 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Nucleotide binding to variants of the HSP70-NBD. To Be Published
5MKS	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
7O6R	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole 分子名称: 1H-indazole, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-12 公開日 2022-05-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODI	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODD	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with tricine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.984 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7ODB	Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-5-sulfanylidene-2H-1,2,4-triazin-3-one, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-04-29 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.662 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. 登録日 2016-11-07 公開日 2016-12-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
7OOE	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226 分子名称: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-05-27 公開日 2021-06-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.369 Å) 主引用文献 Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands To Be Published
7OOH	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 分子名称: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-05-27 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 To Be Published

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