PDB: 313 件ウェブページステータス検索Chemie searchBIRD

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7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex 分子名称: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 He, D.W, You, L.L, Zhang, Y. 登録日 2021-06-06 公開日 2022-07-27 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
4Q5S	Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... 著者 Murakami, K.S. 登録日 2014-04-17 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
4Q4Z	Thermus thermophilus RNA polymerase de novo transcription initiation complex 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ... 著者 Murakami, K.S. 登録日 2014-04-15 公開日 2014-07-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
8FTD	Structure of Escherichia coli CedA in complex with transcription initiation complex 分子名称: CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, M, Vassyliev, N, Nudler, E. 登録日 2023-01-11 公開日 2024-01-10 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 General transcription factor from Escherichia coli with a distinct mechanism of action. Nat.Struct.Mol.Biol., 31, 2024
8GZH	Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 You, L.L, Shen, L.Q, Zhang, Y. 登録日 2022-09-27 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
8GZG	Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Shen, L.Q, You, L.L, Zhang, Y. 登録日 2022-09-27 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
8H40	Cryo-EM structure of the transcription activation complex NtcA-TAC 分子名称: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. 登録日 2022-10-09 公開日 2023-10-04 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8H3V	Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC 分子名称: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. 登録日 2022-10-09 公開日 2023-10-04 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8HKC	Cryo-EM structure of E. coli RNAP sigma32 complex 分子名称: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Wu, S, Ma, L.X. 登録日 2022-11-25 公開日 2023-05-31 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 Structural Insight into the Mechanism of sigma 32-Mediated Transcription Initiation of Bacterial RNA Polymerase. Biomolecules, 13, 2023
8HIH	Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Shi, J, Xu, J.C. 登録日 2022-11-20 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.66 Å) 主引用文献 Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8HVR	Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Wang, Y, Zheng, J. 登録日 2022-12-27 公開日 2023-12-27 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
8IGS	Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. 登録日 2023-02-21 公開日 2023-05-17 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
8IGR	Cryo-EM structure of CII-dependent transcription activation complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. 登録日 2023-02-21 公開日 2023-05-17 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
4XSY	Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme 分子名称: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-22 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.007 Å) 主引用文献 CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4YLP	E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YG2	X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 X-ray crystal structure of Escherichia coli RNA polymerase sigma70 holoenzyme J. Biol. Chem., 288, 2013
4YLO	E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YLN	E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YFX	Escherichia coli RNA polymerase in complex with Myxopyronin B 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.844 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4YFK	Escherichia coli RNA polymerase in complex with squaramide compound 8. 分子名称: 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.571 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4YFN	Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.817 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4ZH2	Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.204 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4ZH3	Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.082 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4ZH4	Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 分子名称: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.993 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
5D4D	Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP 分子名称: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016

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