PDB: 327 件ウェブページステータス検索Chemie searchBIRD

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7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Saecker, R.M, Darst, S.A, Chen, J. 登録日 2021-04-23 公開日 2021-09-29 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7UBM	Transcription antitermination complex: "pre-engaged" Qlambda-loading complex 分子名称: Antitermination protein Q, DNA (52-MER), DNA (53-MER), ... 著者 Yin, Z, Ebright, R.H. 登録日 2022-03-15 公開日 2022-09-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7UBN	Transcription antitermination complex: NusA-containing "engaged" Qlambda-loading complex 分子名称: Antitermination protein, DNA (52-MER), DNA (53-MER), ... 著者 Yin, Z, Ebright, R.H. 登録日 2022-03-15 公開日 2022-09-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
4OIN	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4OIO	Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation 分子名称: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex 分子名称: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Su, M, Ebright, R.H. 登録日 2021-06-04 公開日 2022-06-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
7U22	Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 分子名称: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2022-02-22 公開日 2022-10-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.87 Å) 主引用文献 Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7VWZ	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y, Shi, J. 登録日 2021-11-12 公開日 2022-06-08 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7VWY	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Lin, W, Feng, Y. 登録日 2021-11-12 公開日 2022-06-08 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4.57 Å) 主引用文献 Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
4OIP	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP 分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
7VF9	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 He, D.W, You, L.L, Zhang, Y. 登録日 2021-09-10 公開日 2022-07-27 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.04 Å) 主引用文献 Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7VPD	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with one Zur dimers 分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Yang, X, Zheng, J. 登録日 2021-10-15 公開日 2022-08-03 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.77 Å) 主引用文献 Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer 分子名称: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Yang, X, Zheng, J. 登録日 2021-10-18 公開日 2022-08-03 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
4OIR	Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV 分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.105 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4Q5S	Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... 著者 Murakami, K.S. 登録日 2014-04-17 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
4MQ9	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 分子名称: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. 登録日 2013-09-16 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
6DVD	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) with 6 nt spacer and bromine labelled in position "-11 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*A)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2018-06-23 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.899 Å) 主引用文献 Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6DVE	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF selenomethionine-labelled sigma factor L) with 6 nt spacer 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*GP*AP*GP*TP*AP*AP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2018-06-23 公開日 2019-02-20 最終更新日 2019-02-27 実験手法 X-RAY DIFFRACTION (3.812 Å) 主引用文献 Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019

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