PDB: 156 件ウェブページステータス検索Chemie searchBIRD

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1FIN	CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2 著者 Jeffrey, P.D, Russo, A.A, Pavletich, N.P. 登録日 1996-07-14 公開日 1997-01-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature, 376, 1995
1H1Q	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094 分子名称: 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Davies, T.G, Noble, M.E.M, Endicott, J.A, Johnson, L.N. 登録日 2002-07-21 公開日 2002-09-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor Nat.Struct.Biol., 9, 2002
1H26	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53 分子名称: CELL DIVISION PROTEIN KINASE 2, CELLULAR TUMOR ANTIGEN P53, CYCLIN A2 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
1H1S	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE 著者 Davies, T.G, Noble, M.E.M, Endicott, J.A, Johnson, L.N. 登録日 2002-07-21 公開日 2002-09-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor Nat.Struct.Biol., 9, 2002
1H1P	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058 分子名称: 6-O-CYCLOHEXYLMETHYL GUANINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Davies, T.G, Noble, M.E.M, Endicott, J.A, Johnson, L.N. 登録日 2002-07-21 公開日 2002-09-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor Nat.Struct.Biol., 9, 2002
1GY3	pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... 著者 Cook, A, Lowe, E.D, Chrysina, E.D, Skamnaki, V.T, Oikonomakos, N.G, Johnson, L.N. 登録日 2002-04-19 公開日 2002-04-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism Biochemistry, 41, 2002
1FVV	THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR 分子名称: 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2 著者 Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K. 登録日 2000-09-20 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science, 291, 2001
1H1R	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086 分子名称: 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Davies, T.G, Noble, M.E.M, Endicott, J.A, Johnson, L.N. 登録日 2002-07-21 公開日 2002-09-19 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor. Nat. Struct. Biol., 9, 2002
1H27	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
1E9H	Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound 分子名称: 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A3 著者 Davies, T.G, Tunnah, P, Noble, M.E.M, Endicott, J.A. 登録日 2000-10-16 公開日 2001-10-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate Structure, 9, 2001
1H25	CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
1H24	CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
1H28	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
2UUE	REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors 分子名称: 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID, 4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE, CELL DIVISION PROTEIN KINASE 2, ... 著者 Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. 登録日 2007-03-02 公開日 2007-03-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
2UZB	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 分子名称: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
2UZD	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 分子名称: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
2UZE	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 分子名称: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
2UZL	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 分子名称: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2007-04-30 公開日 2007-06-26 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
2W96	Crystal Structure of CDK4 in complex with a D-type cyclin 分子名称: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1, GLYCEROL 著者 Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. 登録日 2009-01-21 公開日 2009-03-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
2W9Z	Crystal Structure of CDK4 in complex with a D-type cyclin 分子名称: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 著者 Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. 登録日 2009-01-30 公開日 2009-03-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F	Crystal Structure of CDK4 in complex with a D-type cyclin 分子名称: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 著者 Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. 登録日 2009-01-23 公開日 2009-03-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
2WPA	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE, ... 著者 Brasca, M.G, Albanese, C, Alzani, R, Amici, R, Avanzi, N, Ballinari, D, Bischoff, J, Borghi, D, Casale, E, Croci, V, Fiorentini, F, Isacchi, A, Mercurio, C, Nesi, M, Orsini, P, Pastori, W, Pesenti, E, Pevarello, P, Roussel, P, Varasi, M, Volpi, D, Vulpetti, A, Ciomei, M. 登録日 2009-08-03 公開日 2010-02-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing. Bioorg.Med.Chem., 18, 2010
2WIH	STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ... 著者 Brasca, M.G, Amboldi, N, Ballinari, D, Cameron, A.D, Casale, E, Cervi, G, Colombo, M, Colotta, F, Croci, V, Dalessio, R, Fiorentini, F, Isacchi, A, Mercurio, C, Moretti, W, Panzeri, A, Pastori, W, Pevarello, P, Quartieri, F, Roletto, F, Traquandi, G, Vianello, P, Vulpetti, A, Ciomei, M. 登録日 2009-05-13 公開日 2009-07-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor. J.Med.Chem., 52, 2009
2WMB	Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, LINEAR RKLFD, ... 著者 Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M. 登録日 2009-06-30 公開日 2010-09-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A To be Published
2WXV	Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N,1-DIMETHYL-8-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ... 著者 Traquandi, G, Ciomei, M, Ballinari, D, Casale, E, Colombo, N, Croci, V, Fiorentini, F, Isacchi, A, Longo, A, Mercurio, C, Panzeri, A, Pastori, W, Pevarello, P, Volpi, D, Roussel, P, Vulpetti, A, Brasca, M.G. 登録日 2009-11-10 公開日 2010-02-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of Potent Pyrazolo[4,3-H]Quinazoline-3-Carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors. J.Med.Chem., 53, 2010

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