PDB: 341 件ウェブページステータス検索Chemie searchBIRD

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6KIX	Cryo-EM structure of human MLL1-NCP complex, binding mode1 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6PAF	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: GLYCEROL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-11 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.241 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P7Z	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 5-cyclopropyl-N-[1-(methylsulfonyl)piperidin-4-yl]-1,2-oxazole-3-carboxamide, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Bonnette, W.G. 登録日 2019-06-06 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P6K	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-04 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P6G	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-03 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P0R	Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor 分子名称: (3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N-[(pyridin-4-yl)methyl]pyrrolidin-3-amine, Histone-lysine N-methyltransferase SUV39H2, UNKNOWN ATOM OR ION, ... 著者 Halabelian, L, Dong, A, Zeng, H, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2019-05-17 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor to be published
6OX0	SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.755 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX3	SETD3 in Complex with an Actin Peptide with His73 Replaced with Lysine 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin Peptide, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.785 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX1	SETD3 in Complex with an Actin Peptide with Target Histidine Partially Methylated 分子名称: 1,2-ETHANEDIOL, Actin, cytoplasmic 1, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX4	A SETD3 Mutant (N255A) in Complex with an Actin Peptide 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin Peptide, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.294 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX5	A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Actin-histidine N-methyltransferase, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6OX2	SETD3in Complex with an Actin Peptide with the Target Histidine Fully Methylated 分子名称: 1,2-ETHANEDIOL, Actin Peptide, GLYCEROL, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.089 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6O9O	Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-03-14 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
6NZO	Set2 bound to nucleosome 分子名称: DNA (149-MER), Histone H2B 1.1, Histone H3, ... 著者 Halic, M, Bilokapic, S. 登録日 2019-02-14 公開日 2019-08-28 最終更新日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Nucleosome and ubiquitin position Set2 to methylate H3K36. Nat Commun, 10, 2019
6JAT	Crystal structure of SETD3 bound to Actin peptide and SFG 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Actin, gamma-enteric smooth muscle, ... 著者 Li, H, Zheng, Y. 登録日 2019-01-25 公開日 2020-01-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.713 Å) 主引用文献 Crystal structure of SETD3 bound to Actin peptide and SFG to be published
6J9J	crystal structure of SESTD2 in complex with H3.3S31phK36M peptide 分子名称: H3.3S31phK36M(29-42), Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Yang, S, Li, H.T. 登録日 2019-01-23 公開日 2020-02-26 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature, 583, 2020
6N3G	Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol 分子名称: DODECAETHYLENE GLYCOL, ETHANOL, N-lysine methyltransferase SMYD2, ... 著者 Perry, E, Spellmon, N, Brunzelle, J, Yang, Z. 登録日 2018-11-15 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol To be Published
6INE	Crystal Structure of human ASH1L-MRG15 complex 分子名称: GLYCEROL, Histone-lysine N-methyltransferase ASH1L, Mortality factor 4-like protein 1, ... 著者 Hou, P, Huang, C, Liu, C.P, Yu, T, Yin, Y, Zhu, B, Xu, R.M. 登録日 2018-10-25 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. Structure, 27, 2019
6IJL	Crystal structure of SmyD3 in complex with covalent inhibitor 5 分子名称: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ... 著者 Baburajendran, N, Joy, J. 登録日 2018-10-10 公開日 2019-08-14 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. Acs Med.Chem.Lett., 10, 2019
6MON	Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor 分子名称: GLYCEROL, LYS-LEU-NLE-SER-LYS-ARG-GLY, N-lysine methyltransferase SMYD2, ... 著者 Spellmon, N, Cornett, E, Brunzelle, J, Rothbart, S, Yang, Z. 登録日 2018-10-04 公開日 2018-12-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.711 Å) 主引用文献 A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity. Sci Adv, 4, 2018
6ICT	Structure of SETD3 bound to SAH and methylated actin 分子名称: Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... 著者 Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) 登録日 2018-09-07 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 Structural insights into SETD3-mediated histidine methylation on beta-actin. Elife, 8, 2019
6ICV	Structure of SETD3 bound to SAH and unmodified actin 分子名称: Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... 著者 Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) 登録日 2018-09-07 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural insights into SETD3-mediated histidine methylation on beta-actin. Elife, 8, 2019
6MBK	SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, Actin peptide, GLYCEROL, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2018-08-30 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
6MBO	GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine, Histone-lysine N-methyltransferase EHMT1, ... 著者 Horton, J.R, Cheng, X. 登録日 2018-08-30 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.591 Å) 主引用文献 Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J. Med. Chem., 62, 2019
6MBL	SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2018-08-30 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019

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