6BZB
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4GLN
| Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n | 分子名称: | D-RFX001, Vascular endothelial growth factor A | 著者 | Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H. | 登録日 | 2012-08-14 | 公開日 | 2012-09-05 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109, 2012
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1MD6
| High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity | 分子名称: | interleukin 1 family, member 5 (delta) | 著者 | Pei, X.Y, Dunn, E.F, Gay, N.J, O'Neill, L.A. | 登録日 | 2002-08-07 | 公開日 | 2003-09-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity. Biochemistry, 42, 2003
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2GJ4
| Structure of rabbit muscle glycogen phosphorylase in complex with ligand | 分子名称: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, Glycogen phosphorylase, ... | 著者 | Otterbein, L.R, Pannifer, A.D, Tucker, J, Breed, J, Oikonomakos, N.G, Rowsell, S, Pauptit, R.A, Claire, M. | 登録日 | 2006-03-30 | 公開日 | 2007-02-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies. Bioorg.Med.Chem.Lett., 16, 2006
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4GLS
| Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21 | 分子名称: | D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H. | 登録日 | 2012-08-14 | 公開日 | 2012-09-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109, 2012
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1U0E
| Crystal structure of mouse phosphoglucose isomerase | 分子名称: | BETA-MERCAPTOETHANOL, GLYCEROL, Glucose-6-phosphate isomerase, ... | 著者 | Solomons, J.T.G, Zimmerly, E.M, Burns, S, Krishnamurthy, N, Swan, M.K, Krings, S, Muirhead, H, Chirgwin, J, Davies, C. | 登録日 | 2004-07-13 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J.Mol.Biol., 342, 2004
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2H8O
| The 1.6A crystal structure of the geranyltransferase from Agrobacterium tumefaciens | 分子名称: | Geranyltranstransferase | 著者 | Zhang, R, Xu, X, Gu, J, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-06-07 | 公開日 | 2006-07-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The 1.6A crystal structure of the geranyltransferase from Agrobacterium tumefaciens To be Published
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4X39
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3O4W
| Crystal structure of dimeric KlHxk1 in crystal form IV | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Hexokinase, ... | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | 登録日 | 2010-07-27 | 公開日 | 2010-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION. J.Biol.Chem., 285, 2010
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5QQ9
| PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with FMOOA000567a | 分子名称: | 2-[(2R,5R,6S)-5-hydroxy-1,2,4,5,6,7-hexahydro-3H-2,6-methanoazocino[5,4-b]indol-3-yl]acetamide, ACETATE ION, Farnesyl diphosphate synthase, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library To Be Published
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5QPS
| PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with FMOPL000644a | 分子名称: | ACETATE ION, Farnesyl diphosphate synthase, SULFATE ION, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library To Be Published
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5QQ7
| PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with FMOOA000562a | 分子名称: | ACETATE ION, Farnesyl diphosphate synthase, SULFATE ION, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library To Be Published
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6R0B
| T. cruzi FPPS in complex with 3-((4-(5-chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)methyl)-1H-indol-5-ol | 分子名称: | 3-[[4-(5-chloranyl-1,3-benzothiazol-2-yl)piperazin-1-yl]methyl]-1~{H}-indol-5-ol, Farnesyl diphosphate synthase, SULFATE ION, ... | 著者 | Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.612 Å) | 主引用文献 | Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
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5QQC
| Crystal Structure of T. cruzi FPPS after initial refinement with no ligand modelled (structure $n) | 分子名称: | ACETATE ION, Farnesyl diphosphate synthase, MAGNESIUM ION, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-14 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | PanDDA analysis group deposition of ground-state model - FPPS screened against the DSI Fragment Library To Be Published
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5QPZ
| PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with FMOPL000524a | 分子名称: | 1-[2-methyl-1,3-bis(oxidanyl)propan-2-yl]-3-phenyl-urea, ACETATE ION, Farnesyl diphosphate synthase, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library To Be Published
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5QQ8
| PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with FMOOA000563a | 分子名称: | 3-ethyl-1-[(1~{R},8~{S},9~{S},10~{S})-10-oxidanyl-11-oxatricyclo[6.2.1.0^{2,7}]undeca-2(7),3,5-trien-9-yl]imidazolidine-2,4-dione, ACETATE ION, Farnesyl diphosphate synthase, ... | 著者 | Petrick, J.K, Nelson, E.R, Muenzker, L, Krojer, T, Douangamath, A, Brandao-Neto, J, von Delft, F, Dekker, C, Jahnke, W. | 登録日 | 2019-03-12 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library To Be Published
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1IAT
| CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR | 分子名称: | BETA-MERCAPTOETHANOL, PHOSPHOGLUCOSE ISOMERASE, SULFATE ION | 著者 | Read, J.A, Pearce, J, Li, X, Muirhead, H, Chirgwin, J, Davies, C. | 登録日 | 2001-03-23 | 公開日 | 2001-05-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia. J.Mol.Biol., 309, 2001
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6SF8
| Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j51 | 分子名称: | 3-[(4E)-4-imino-5,6-dimethylfuro[2,3-d]pyrimidin-3(4H)-yl]-N,N-dimethylpropan-1-amine, Farnesyl diphosphate synthase, SULFATE ION | 著者 | Magari, F, Heine, A, Klebe, G. | 登録日 | 2019-08-01 | 公開日 | 2020-08-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment j51 To Be Published
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5R8J
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5GHU
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4X37
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8CGK
| Lincomycin and Avilamycin bound to the 50S subunit | 分子名称: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | 登録日 | 2023-02-05 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.64 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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5QTD
| Unliganded T. brucei FPPS | 分子名称: | Farnesyl pyrophosphate synthase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W. | 登録日 | 2019-08-09 | 公開日 | 2020-10-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.642 Å) | 主引用文献 | Unliganded T. brucei FPPS To Be Published
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5QTC
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8A6U
| PcIDS1 in complex with Mg2+ | 分子名称: | Isoprenyl diphosphate synthase, MAGNESIUM ION | 著者 | Ecker, F, Boland, W, Groll, M. | 登録日 | 2022-06-20 | 公開日 | 2023-05-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors. Nat.Chem., 15, 2023
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