6NLE
| X-ray structure of LeuT with V269 deletion | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Navratna, V, Yang, D, Gouaux, E. | 登録日 | 2019-01-08 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.615 Å) | 主引用文献 | Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion inSLC6A3. Proc.Natl.Acad.Sci.USA, 116, 2019
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7LWD
| Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ... | 著者 | Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J. | 登録日 | 2021-03-01 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nat Commun, 12, 2021
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7LI9
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7LI6
| apo SERT reconstituted in lipid nanodisc in KCl | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | 著者 | Yang, D, Gouaux, E. | 登録日 | 2021-01-26 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
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7LI8
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7LIA
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7LI7
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7MGW
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7LQK
| Crystal structure of the R375A mutant of LeuT | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | 登録日 | 2021-02-13 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
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7LQJ
| Crystal structure of LeuT bound to L-Alanine | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | 登録日 | 2021-02-13 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
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7LQL
| Crystal structure of the R375D mutant of LeuT | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | 登録日 | 2021-02-13 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife, 10, 2021
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7WGD
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7WLW
| X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with SKF89976a | 分子名称: | (3S)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid, Antibody Fragment heavy chain, Antibody fragment light chain, ... | 著者 | Penmatsa, A, Joseph, D. | 登録日 | 2022-01-13 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter. Embo J., 41, 2022
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7WGT
| X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with NO711. | 分子名称: | 1-(2-{[(diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid, Antibody fragment (9D5) heavy chain, Antibody fragment (9D5) light chain, ... | 著者 | Joseph, D, Penmatsa, A. | 登録日 | 2021-12-28 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter. Embo J., 41, 2022
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7Y7Y
| Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom | 分子名称: | (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7V
| Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1 | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7Z
| Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7W
| Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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4XP4
| X-ray structure of Drosophila dopamine transporter in complex with cocaine | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNU
| X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | 分子名称: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XPF
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55 | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.273 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPG
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to beta-CFT or Win35428 | 分子名称: | CHLORIDE ION, CHOLESTEROL, Dopamine transporter, ... | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP1
| X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gouaux, E, Penmatsa, A, Wang, K. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP5
| X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55 | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | 著者 | Gouaux, E, Penmatsa, A, Wang, K. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPB
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine | 分子名称: | Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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