7T6M
| Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1 | 分子名称: | Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Rep, 39, 2022
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7T6P
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4G8L
| Active state of intact sensor domain of human RNase L with 2-5A bound | 分子名称: | 2-5A-dependent ribonuclease, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE | 著者 | Han, Y, Whitney, G, Donovan, J, Korennykh, A. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes. Cell Rep, 2, 2012
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7T4X
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7WM1
| Cryo-EM structure of AKT1-AtKC1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1, ... | 著者 | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | 登録日 | 2022-01-14 | 公開日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the regulation mechanism of a hyper polarization-activated K+ channel AKT1 by AtKC1 To Be Published
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6O1U
| Cryo-EM structure of TRPV5 W583A in nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-21 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
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3JXJ
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6PQQ
| Cryo-EM structure of human TRPA1 C621S mutant in the apo state | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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8V6O
| Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-aminoethyl diphenylborinate, SODIUM ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-12-01 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10, 2024
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7B0J
| TRPC4 in LMNG detergent | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CALCIUM ION, Transient receptor potential cation channel subfamily c member 4a | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-20 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7S8C
| Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
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4DX1
| Crystal structure of the human TRPV4 ankyrin repeat domain | 分子名称: | GLYCEROL, PHOSPHATE ION, Transient receptor potential cation channel subfamily V member 4 | 著者 | Inada, H, Gaudet, R. | 登録日 | 2012-02-27 | 公開日 | 2012-07-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 2012
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8TF4
| Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | 登録日 | 2023-07-07 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
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6PQO
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6AEI
| Cryo-EM structure of the receptor-activated TRPC5 ion channel | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | 著者 | Duan, J, Li, Z, Li, J, Zhang, J. | 登録日 | 2018-08-05 | 公開日 | 2019-08-07 | 最終更新日 | 2019-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Cryo-EM structure of TRPC5 at 2.8- angstrom resolution reveals unique and conserved structural elements essential for channel function. Sci Adv, 5, 2019
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7T6N
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8CTE
| Class 2 of erythrocyte ankyrin-1 complex (Composite map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ammonium transporter Rh type A, Ankyrin-1, ... | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | 登録日 | 2022-05-14 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex. Nat.Struct.Mol.Biol., 29, 2022
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7MZD
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8GF8
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | 分子名称: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2023-03-07 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
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6O1N
| Cryo-EM structure of TRPV5 (1-660) in nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-21 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
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8U3J
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7FCV
| Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana | 分子名称: | PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1 | 著者 | Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L. | 登録日 | 2021-07-15 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis. Nat Commun, 13, 2022
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5D68
| Crystal structure of KRIT1 ARD-FERM | 分子名称: | Krev interaction trapped protein 1 | 著者 | Zhang, R, Li, X, Boggon, T.J. | 登録日 | 2015-08-11 | 公開日 | 2015-10-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.908 Å) | 主引用文献 | Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J.Struct.Biol., 192, 2015
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7MZ6
| Cryo-EM structure of minimal TRPV1 with 1 perturbed PI | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2021-05-24 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7XJ1
| Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | 登録日 | 2022-04-14 | 公開日 | 2022-11-09 | 最終更新日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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