6Y5C
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![BU of 6y5c by Molmil](/molmil-images/mine/6y5c) | The crystal structure of glycogen phosphorylase in complex with 52 | 分子名称: | 2-(4-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form | 著者 | Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. | 登録日 | 2020-02-25 | 公開日 | 2020-08-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
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8A5W
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![BU of 8a5w by Molmil](/molmil-images/mine/8a5w) | Crystal structure of the human phosphoserine aminotransferase (PSAT) in complex with O-phosphoserine | 分子名称: | (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid, (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Costanzi, E, Demitri, N, Ullah, R, Marchesan, F, Peracchi, A, Zangelmi, E, Storici, P, Campanini, B. | 登録日 | 2022-06-16 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase. Protein Sci., 32, 2023
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8FNV
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![BU of 8fnv by Molmil](/molmil-images/mine/8fnv) | Structure of RdrB from Escherichia coli RADAR defense system | 分子名称: | Adenosine deaminase, ZINC ION | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | 登録日 | 2022-12-28 | 公開日 | 2023-02-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
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7PE3
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8FNU
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![BU of 8fnu by Molmil](/molmil-images/mine/8fnu) | Structure of RdrA from Streptococcus suis RADAR defense system | 分子名称: | KAP NTPase domain-containing protein | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | 登録日 | 2022-12-28 | 公開日 | 2023-02-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
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1BHQ
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![BU of 1bhq by Molmil](/molmil-images/mine/1bhq) | MAC-1 I DOMAIN CADMIUM COMPLEX | 分子名称: | ACETYL GROUP, CADMIUM ION, CD11B | 著者 | Baldwin, E.T. | 登録日 | 1998-06-10 | 公開日 | 1998-11-04 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Cation binding to the integrin CD11b I domain and activation model assessment Structure, 6, 1998
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7L02
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![BU of 7l02 by Molmil](/molmil-images/mine/7l02) | Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ... | 著者 | Manne, K, Henderson, R, Acharya, P. | 登録日 | 2020-12-10 | 公開日 | 2020-12-30 | 最終更新日 | 2021-06-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021
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7ZNK
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![BU of 7znk by Molmil](/molmil-images/mine/7znk) | Structure of an endogenous human TREX complex bound to mRNA | 分子名称: | RNA, Spliceosome RNA helicase DDX39B, THO complex subunit 1, ... | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | 登録日 | 2022-04-21 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
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6F4H
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![BU of 6f4h by Molmil](/molmil-images/mine/6f4h) | Crystal structure of the Drosophila melanogaster SNF/U1-SL2 complex | 分子名称: | CITRATE ANION, U1 small nuclear ribonucleoprotein A, U1-SL2 | 著者 | Weber, G, Holton, N, Hall, K.B, DeKoster, G, Wahl, M.C. | 登録日 | 2017-11-29 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular principles underlying dual RNA specificity in the Drosophila SNF protein. Nat Commun, 9, 2018
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7PU4
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1BHO
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![BU of 1bho by Molmil](/molmil-images/mine/1bho) | MAC-1 I DOMAIN MAGNESIUM COMPLEX | 分子名称: | CD11B, MAGNESIUM ION | 著者 | Baldwin, E.T. | 登録日 | 1998-06-10 | 公開日 | 1998-11-04 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Cation binding to the integrin CD11b I domain and activation model assessment Structure, 6, 1998
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6PCR
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![BU of 6pcr by Molmil](/molmil-images/mine/6pcr) | E. coli 50S ribosome bound to compound 40o | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl (2-bromopyridin-4-yl)carbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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5IQT
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![BU of 5iqt by Molmil](/molmil-images/mine/5iqt) | WelO5 bound to Fe(II), Cl, 2-oxoglutarate, and 12-epifischerindole U | 分子名称: | (6aS,9R,10R,10aS)-9-ethyl-10-isocyano-6,6,9-trimethyl-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Mitchell, A.J, Boal, A.K. | 登録日 | 2016-03-11 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5. Nat.Chem.Biol., 12, 2016
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7ZNL
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![BU of 7znl by Molmil](/molmil-images/mine/7znl) | Structure of the human TREX core THO-UAP56 complex | 分子名称: | Spliceosome RNA helicase DDX39B, THO complex subunit 1, THO complex subunit 2, ... | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | 登録日 | 2022-04-21 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
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6Y2L
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![BU of 6y2l by Molmil](/molmil-images/mine/6y2l) | Structure of human ribosome in POST state | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | 著者 | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | 登録日 | 2020-02-16 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
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5KSG
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8FBY
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5KU7
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6ME7
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![BU of 6me7 by Molmil](/molmil-images/mine/6me7) | XFEL crystal structure of human melatonin receptor MT2 (H208A) in complex with 2-phenylmelatonin | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, ... | 著者 | Johansson, L.C, Stauch, B, McCorvy, J, Han, G.W, Patel, N, Batyuk, A, Gati, C, Li, C, Grandner, J, Hao, S, Olsen, R.H.J, Tribo, A.R, Zaare, S, Zhu, L, Zatsepin, N.A, Weierstall, U, Liu, W, Roth, B.L, Katritch, V, Cherezov, V. | 登録日 | 2018-09-05 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity. Nature, 569, 2019
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8D4S
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![BU of 8d4s by Molmil](/molmil-images/mine/8d4s) | Crystal Structure of Cathepsin G Inhibited by Eap1 from S. aureus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin G, C-terminal truncated form, ... | 著者 | Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. | 登録日 | 2022-06-02 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023
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6PC5
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![BU of 6pc5 by Molmil](/molmil-images/mine/6pc5) | E. coli 50S ribosome bound to compounds 46 and VS1 | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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8DCQ
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7QBS
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![BU of 7qbs by Molmil](/molmil-images/mine/7qbs) | B12-dependent radical SAM methyltransferase, Mmp10 with [4Fe-4S] cluster, cobalamin, S-adenosyl-L-methionine, and peptide bound. | 分子名称: | CO-METHYLCOBALAMIN, FE (III) ION, IRON/SULFUR CLUSTER, ... | 著者 | Bernardo-Garcia, N, Fyfe, C.D, Chavas, L.M.G, Legrand, P, Benjdia, A, Berteau, O. | 登録日 | 2021-11-19 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.327 Å) | 主引用文献 | Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase. Nature, 602, 2022
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5KSN
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8FFU
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![BU of 8ffu by Molmil](/molmil-images/mine/8ffu) | Structure of GntC, a PLP-dependent enzyme catalyzing L-enduracididine biosynthesis from (S)-4-hydroxy-L-arginine, with the substrate bound | 分子名称: | (2S,4S)-5-carbamimidamido-4-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pentanoic acid (non-preferred name), Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, MAGNESIUM ION | 著者 | Chen, P.Y.-T, Moore, B.S. | 登録日 | 2022-12-10 | 公開日 | 2023-04-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Mechanistic and Structural Insights into a Divergent PLP-Dependent l-Enduracididine Cyclase from a Toxic Cyanobacterium. Acs Catalysis, 13, 2023
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