6Y5C

The crystal structure of glycogen phosphorylase in complex with 52

Summary for 6Y5C

Entry DOI	10.2210/pdb6y5c/pdb
Descriptor	Glycogen phosphorylase, muscle form, 2-(4-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one (3 entities in total)
Functional Keywords	transferase, glycogen metabolism
Biological source	Oryctolagus cuniculus (Rabbit)
Total number of polymer chains	1
Total formula weight	97787.58
Authors	Kyriakis, E.,Koulas, S.M.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2020-02-25, release date: 2020-08-19)
Primary citation	Chetter, B.A.,Kyriakis, E.,Barr, D.,Karra, A.G.,Katsidou, E.,Koulas, S.M.,Skamnaki, V.T.,Snape, T.J.,Psarra, A.G.,Leonidas, D.D.,Hayes, J.M. Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102:104003-104003, 2020 Cited by PubMed: 32771768 DOI: 10.1016/j.bioorg.2020.104003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation