8FFU

Structure of GntC, a PLP-dependent enzyme catalyzing L-enduracididine biosynthesis from (S)-4-hydroxy-L-arginine, with the substrate bound

Summary for 8FFU

Entry DOI	10.2210/pdb8ffu/pdb
Related	8FFT
Descriptor	Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, MAGNESIUM ION, (2S,4S)-5-carbamimidamido-4-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pentanoic acid (non-preferred name), ... (5 entities in total)
Functional Keywords	plp, gntc, cyclodehydration, (s)-4-hydroxy-l-arginine, guanitoxin, l-enduracididine, cyanobacterial blooms, biocatalysis, biosynthesis, cyanobacterium, biosynthetic protein
Biological source	Dolichospermum flos-aquae More
Total number of polymer chains	4
Total formula weight	167942.38
Authors	Chen, P.Y.-T.,Moore, B.S. (deposition date: 2022-12-10, release date: 2023-04-12, Last modification date: 2023-11-15)
Primary citation	Cordoza, J.L.,Chen, P.Y.,Blaustein, L.R.,Lima, S.T.,Fiore, M.F.,Chekan, J.R.,Moore, B.S.,McKinnie, S.M.K. Mechanistic and Structural Insights into a Divergent PLP-Dependent l-Enduracididine Cyclase from a Toxic Cyanobacterium. Acs Catalysis, 13:9817-9828, 2023 Cited by PubMed: 37497377 DOI: 10.1021/acscatal.3c01294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation