3GCV
 
 | | Human P38 MAP Kinase in Complex with RL62 | | 分子名称: | 1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2009-02-22 | | 公開日 | 2009-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
J.Am.Chem.Soc., 131, 2009
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4NAW
 | | Crystal Structure of Human ATG12~ATG5-ATG16N in complex with a fragment of ATG3 | | 分子名称: | Autophagy protein 5, Autophagy-related protein 16-1, SODIUM ION, ... | | 著者 | Metlagel, Z, Otomo, C, Takaesu, G, Otomo, T. | | 登録日 | 2013-10-22 | | 公開日 | 2013-11-06 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | | 主引用文献 | Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5WQE
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4NCD
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5VWY
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5C7M
 | | CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT | | 分子名称: | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C | | 著者 | Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2015-06-24 | | 公開日 | 2016-03-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | | 主引用文献 | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
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5VX3
 | | Bcl-xL in complex with Bim-h3Pc-RT | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11 | | 著者 | Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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7XHF
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2X7D
 | | Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron | | 分子名称: | (4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | | 著者 | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | | 登録日 | 2010-02-26 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
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4K4F
 | | Co-crystal structure of TNKS1 with compound 18 [4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-(quinolin-8-yl)benzamide] | | 分子名称: | 4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-N-(quinolin-8-yl)benzamide, Tankyrase-1, ZINC ION | | 著者 | Huang, X, Bregman, H, Wilson, C, DiMauro, E, Gunaydin, H. | | 登録日 | 2013-04-12 | | 公開日 | 2013-06-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
J.Med.Chem., 56, 2013
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5W5G
 | | Structure of Human Sts-1 histidine phosphatase domain | | 分子名称: | Ubiquitin-associated and SH3 domain-containing protein B | | 著者 | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | | 登録日 | 2017-06-15 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.
Biochemistry, 56, 2017
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7XHG
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5VWX
 | | Bak core latch dimer in complex with Bim-h0-h3Glt | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11 | | 著者 | Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.489 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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7XLQ
 | | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y. | | 登録日 | 2022-04-22 | | 公開日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Nat Commun, 14, 2023
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4TJU
 | | Crystal Structure of human Tankyrase 2 in complex with 3,4-CPQ-5-C. | | 分子名称: | 3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE, Tankyrase-2, ZINC ION | | 著者 | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | | 登録日 | 2014-05-25 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
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5C3G
 | | Crystal structure of Bcl-xl bound to BIM-MM | | 分子名称: | Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11 | | 著者 | Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J. | | 登録日 | 2015-06-17 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.
Chem Sci, 7, 2016
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4RPD
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3FCC
 | | CRYSTAL STRUCTURE OF DLTA PROTEIN IN COMPLEX WITH ATP and MAGNESIUM | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, D-alanine--poly(phosphoribitol) ligase subunit 1, MAGNESIUM ION | | 著者 | Osman, K.T, Du, L, He, Y, Luo, Y. | | 登録日 | 2008-11-21 | | 公開日 | 2009-04-14 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP.
J.Mol.Biol., 388, 2009
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5W0N
 | | Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, IODIDE ION, MAGNESIUM ION, ... | | 著者 | Faehnle, C.R, Walleshauser, J, Joshua-Tor, L. | | 登録日 | 2017-05-31 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Nat. Struct. Mol. Biol., 24, 2017
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2WD5
 | | SMC hinge heterodimer (Mouse) | | 分子名称: | STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1A, STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 | | 著者 | Michie, K.A, Haering, C.H, Nasmyth, K, Lowe, J. | | 登録日 | 2009-03-20 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A Positively Charged Channel within the Smc1/Smc3 Hinge Required for Sister Chromatid Cohesion.
Embo J., 30, 2011
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5D77
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7W3N
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5CTR
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4PKY
 | | ARNT/HIF transcription factor/coactivator complex | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, SULFATE ION, ... | | 著者 | Tomchick, D.R, Partch, C.L, Gardner, K.H. | | 登録日 | 2014-05-15 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization.
J.Biol.Chem., 290, 2015
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7WU7
 | | Prefoldin-tubulin-TRiC complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Prefoldin subunit 1, Prefoldin subunit 2, ... | | 著者 | Gestaut, D, Zhao, Y, Park, J, Ma, B, Leitner, A, Collier, M, Pintilie, G, Roh, S.-H, Chiu, W, Frydman, J. | | 登録日 | 2022-02-07 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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