8H05
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8RRR
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8RQM
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8PK2
| Cryo EM structure of the type 1m polymorph of alpha-synuclein | 分子名称: | Alpha-synuclein | 著者 | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | 登録日 | 2023-06-24 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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8PIX
| Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH. | 分子名称: | Alpha-synuclein | 著者 | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | 登録日 | 2023-06-22 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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8PJO
| Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH. | 分子名称: | Alpha-synuclein, CHLORIDE ION | 著者 | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | 登録日 | 2023-06-23 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.31 Å) | 主引用文献 | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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8PK4
| Cryo EM structure of the type 5A polymorph of alpha-synuclein. | 分子名称: | Alpha-synuclein | 著者 | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | 登録日 | 2023-06-24 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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6SST
| cryo-em structure of alpha-synuclein fibril polymorph 2B | 分子名称: | Alpha-synuclein | 著者 | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | 登録日 | 2019-09-09 | 公開日 | 2019-12-18 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
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6SSX
| cryo-em structure of alpha-synuclein fibril polymorph 2A | 分子名称: | Alpha-synuclein | 著者 | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | 登録日 | 2019-09-09 | 公開日 | 2019-12-18 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
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6UFR
| Structure of recombinantly assembled E46K alpha-synuclein fibrils | 分子名称: | Alpha-synuclein | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | 登録日 | 2019-09-24 | 公開日 | 2020-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117, 2020
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7YNQ
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7YNT
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7YNM
| ThT-bound alpha-synuclein fibrils conformation 1 | 分子名称: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-31 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | ThT-bound alpha-synuclein fibrils conformation 1 To Be Published
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7YNL
| EB-bound alpha-synuclein fibrils | 分子名称: | 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid, Alpha-synuclein | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-31 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | EB-bound alpha-synuclein fibrils To Be Published
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7YNR
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7YNP
| BF227-bound alpha-synuclein fibrils | 分子名称: | 5-[(~{E})-2-(6-methoxy-1,3-benzoxazol-2-yl)ethenyl]-~{N},~{N}-dimethyl-1,3-thiazol-2-amine, Alpha-synuclein | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-31 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | BF227-bound alpha-synuclein fibrils To Be Published
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7YNN
| ThT-bound alpha-synuclein fibrils conformation 2 | 分子名称: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-31 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | ThT-bound alpha-synuclein fibrils conformation 2 To Be Published
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7YNO
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7YNG
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7YNS
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7YNF
| CCA-bound alpha-synuclein fibrils | 分子名称: | Alpha-synuclein, copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-30 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | CCA-bound alpha-synuclein fibrils To Be Published
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8A9L
| Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | 分子名称: | Alpha-synuclein, Unknown fragment | 著者 | Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. | 登録日 | 2022-06-28 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610, 2022
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8ADW
| Lipidic alpha-synuclein fibril - polymorph L1C | 分子名称: | Alpha-synuclein | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | 登録日 | 2022-07-11 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8ADU
| Lipidic alpha-synuclein fibril - polymorph L1A | 分子名称: | Alpha-synuclein | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | 登録日 | 2022-07-11 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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8AEX
| Lipidic alpha-synuclein fibril - polymorph L3A | 分子名称: | Alpha-synuclein | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | 登録日 | 2022-07-14 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein. Nat Commun, 13, 2022
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